NDLI: Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots

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Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots

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Metallomics Vol - 6 Issue - 3

Metallomics Vol - 6 Issue - 2

Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots

Content Provider	Royal Society of Chemistry (RSC)
Author	Bastien, Olivier Hugouvieux, Véronique Aranjuelo, Iker Rivasseau, Corinne Combes, Florence Berthet, Serge Bourguignon, Jacques Leonhardt, Nathalie Renou, Jean-Pierre Doustaly, Fany Carrière, Marie Fiévet, Julie B. Vavasseur, Alain Vandenbrouck, Yves
Copyright Year	2014
Abstract	Uranium is a natural element which is mainly redistributed in the environment due to human activity, including accidents and spillages. Plants may be useful in cleaning up after incidents, although little is yet known about the relationship between metal speciation and plant response. Here, J-Chess modeling was used to predict U speciation and exposure conditions affecting U bioavailability for plants. The model was confirmed by exposing Arabidopsis thaliana plants to U under hydroponic conditions. The early root response was characterized using complete Arabidopsis transcriptome microarrays (CATMA). Expression of 111 genes was modified at the three timepoints studied. The associated biological processes were further examined by real-time quantitative RT-PCR. Annotation revealed that oxidative stress, cell wall and hormone biosynthesis, and signaling pathways (including phosphate signaling) were affected by U exposure. The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl. A network calculated using IRT1, FRO2 and FIT1 as bait revealed a set of genes whose expression levels change under U stress. Hypotheses are presented to explain how U perturbs the iron uptake and signaling response. These results give preliminary insights into the pathways affected by uranyl uptake, which will be of interest for engineering plants to help clean areas contaminated with U.
Starting Page	809
Ending Page	821
Page Count	13
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	6
Issue Number	4
Journal	Metallomics
DOI	10.1039/c4mt00005f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Arabidopsis thaliana Oxidative stress Plant hormone Hydroponics Phosphate Transcriptome Bioavailability Reverse transcription polymerase chain reaction Uranyl Speciation Cell wall
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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