NDLI: Is aging recorded in blood Cu and Zn isotope compositions?

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Metallomics Vol - 5 Issue - 7

Metallomics Vol - 5 Issue - 6

Metallomics Vol - 5 Issue - 5

Metallomics Vol - 5 Issue - 4

Metallomics Vol - 5 Issue - 3

Metallomics Vol - 5 Issue - 2

Is aging recorded in blood Cu and Zn isotope compositions?

Content Provider	Royal Society of Chemistry (RSC)
Author	Balter, Vincent Alekseev, Anatoly N. Lamboux, Aline Albarède, Francis Crubézy, Eric Telouk, Philippe Jaouen, Klervia Gibert, Morgane Fourel, François
Copyright Year	2013
Abstract	Recent isotopic observations of animal samples indicate body accumulation of heavy zinc and light copper throughout life. This hypothesis has never been tested for humans, but the existence of a relationship between blood isotopic composition and age could be promising for age assessment methodologies. Dietary habits can also influence the blood zinc isotope composition, being an additional source of isotopic variation. In order to reduce this putative source of variation, we selected a population living in an isolated area (Sakha Republic, Russia) where diverse foods are of limited availability. We sampled blood from 8 male and 31 female Yakut volunteers between the ages of 18 and 74. Zinc, iron and copper were purified by liquid chromatography on ion exchange resin and their stable isotope ratios were measured using multiple-collector inductively coupled plasma mass spectrometry. According to observations of animal samples, the 66Zn/64Zn ratio increases with age. We also observe that the 65Cu/63Cu ratio decreases with age, whereas iron isotopic compositions are unrelated to age. The copper and zinc isotope compositions of the Yakut's blood are significantly lighter and heavier, respectively, than in samples of European and Japanese populations. The Yakut is a circumpolar population in which individuals have an elevated basal metabolic rate in response to cold stress. This elevated basal metabolic rate could enhance copper and zinc isotopic fractionation by accelerating the turnover of the copper and zinc stores.
Starting Page	1016
Ending Page	1024
Page Count	9
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	5
Issue Number	8
Journal	Metallomics
DOI	10.1039/c3mt00085k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Isotope Basal metabolic rate Ion Isotope fractionation Sakha Republic Zinc Chromatography Russia Yakut Resin Yakuts Inductively coupled plasma mass spectrometry Copper
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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