NDLI: Campylobacter jejuni ferric–enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores

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Campylobacter jejuni ferric–enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores

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Metallomics Vol - 5 Issue - 7

Metallomics Vol - 5 Issue - 6

Metallomics Vol - 5 Issue - 5

Metallomics Vol - 5 Issue - 4

Metallomics Vol - 5 Issue - 3

Metallomics Vol - 5 Issue - 2

Campylobacter jejuni ferric–enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores

Content Provider	Royal Society of Chemistry (RSC)
Author	Flint, Annika Butcher, James Stintzi, Alain Xu, Jide Naikare, Hemant Raymond, Kenneth N.
Copyright Year	2013
Abstract	Campylobacter jejuni NCTC11168 does not produce any endogenous siderophores of its own yet requires the CfrA enterobactin transporter for in vivo colonization. In addition, the genome of C. jejuni NCTC11168 contains three distinct TonB energy transduction systems, named TonB1, TonB2, and TonB3, that have not been tested for their role in siderophore uptake or their functional redundancy. We demonstrate that C. jejuni NCTC11168 transports ferric–enterobactin in an energy dependent manner that requires TonB3 for full activity with TonB1 showing partial functional redundancy. Moreover C. jejuni NCTC11168 can utilize a wide variety of structurally different catechol siderophores as sole iron sources during growth. This growth is solely dependent on the CfrA enterobactin transporter and highlights the wide range of substrates that this transporter can recognize. TonB3 is also required for growth on most catechol siderophores. Furthermore, either TonB1 or TonB3 is sufficient for growth on hemin or hemoglobin as a sole iron source demonstrating functional redundancy between TonB1 and TonB3. In vivo colonization assays with isogenic deletion mutants revealed that both TonB1 and TonB3 are required for chick colonization with TonB2 dispensable in this model. These results further highlight the importance of iron transport for efficient C. jejuni colonization.
Starting Page	988
Ending Page	996
Page Count	9
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	5
Issue Number	8
Journal	Metallomics
DOI	10.1039/c3mt20254b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hemin Siderophore Hemoglobin Catechol Enterobactin Genome Outer membrane receptor Campylobacter jejuni
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Campylobacter jejuni ferric-enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores

Expression, Purification, and Structural Characterization of CfrA, a Putative Iron Transporter from Campylobacter jejuni � (2008)

Molecular, antigenic, and functional characteristics of ferric enterobactin receptor cfra in campylobacter jejuni (2009).

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Campylobacter jejuni ferric–enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores

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Campylobacter jejuni ferric–enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores