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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Messori, Luigi Magherini, Francesca Bini, Luca Puglia, Michele Modesti, Alessandra Cinellu, Maria Agostina Landini, Ida Gabbiani, Chiara Guidi, Francesca Nobili, Stefania Fiaschi, Tania Mini, Enrico |
| Copyright Year | 2012 |
| Abstract | Platinum-based chemotherapy is the primary treatment for human ovarian cancer. Overcoming platinum resistance has become a critical issue in the current chemotherapeutic strategies of ovarian cancer as drug resistance is the main reason for treatment failure. Cytotoxic gold compounds hold great promise to reach this goal; however, their modes of action are still largely unknown. To shed light on the underlying molecular mechanisms, we performed 2-DE and MS analysis to identify differential protein expression in a cisplatin-resistant human ovarian cancer cell line (A2780/R) following treatment with two representative gold compounds, namely Auranofin and Auoxo6. It is shown that Auranofin mainly acts by altering the expression of Proteasome proteins while Auoxo6 mostly modifies proteins related to mRNA splicing, trafficking and stability. We also found that Thioredoxin-like protein 1 expression is greatly reduced after treatment with both gold compounds. These results are highly indicative of the likely sites of action of the two tested gold drugs and of the affected cellular functions. The implications of the obtained results are thoroughly discussed in the frame of current knowledge on cytotoxic gold agents. |
| Starting Page | 307 |
| Ending Page | 314 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 17565901 |
| Volume Number | 4 |
| Issue Number | 3 |
| Journal | Metallomics |
| DOI | 10.1039/c2mt00083k |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Chemotherapy Messenger RNA Cytotoxicity Protein Auranofin Ovarian cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics |
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