NDLI: Decreased copper concentrations but increased lysyl oxidase activity in ischemic hearts of rhesus monkeys

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Metallomics Vol - 8 Issue - 8

Metallomics Vol - 8 Issue - 7

Metallomics Vol - 8 Issue - 6

Metallomics Vol - 8 Issue - 5

Metallomics Vol - 8 Issue - 4

Metallomics Vol - 8 Issue - 3

Metallomics Vol - 8 Issue - 2

Decreased copper concentrations but increased lysyl oxidase activity in ischemic hearts of rhesus monkeys

Content Provider	Royal Society of Chemistry (RSC)
Author	Nie, Xin Xiao, Ying Kang, Y. James Han, Pengfei Fu, Haiying
Copyright Year	2016
Abstract	Myocardial ischemia leads to a decrease in copper (Cu) concentrations, along with collagen deposition in which Cu-dependent lysyl oxidase (LOX) catalyzes the cross-linking of collagens leading to tissue stiffness. The present study was undertaken to determine the relationship between decreased Cu concentrations and LOX activities in ischemic hearts of monkeys. Rhesus monkeys were subjected to coronary artery ligation, leading to ischemic infarction. At 8 weeks after the surgery, Cu concentrations and Cu-dependent cytochrome c oxidase (CCO) activities in the infarct area were significantly decreased. Unexpectedly, the Cu-dependent LOX activities in the same area were significantly increased. LOX proteins were accumulated in the cytosol of myofibroblasts, endothelial cells, and residual cardiomyocytes in the infarct area. In contrast, LOX was only found in fibroblasts and myocardial intercalated discs between cardiomyocytes in sham-operated controls. The LOX mRNA level was also increased in the infarct area compared to the sham operated control. This upregulation of LOX was associated with significant increases in collagen deposition; protein levels of type I and III collagens were significantly increased along with increases in their mRNA levels in the infarct area. This finding indicates that under myocardial infarction, Cu-dependent CCO activities were depressed but LOX activities were increased most likely through Cu redistribution although Cu concentrations were significantly depressed.
Starting Page	973
Ending Page	980
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	9
Journal	Metallomics
DOI	10.1039/c6mt00037a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxygen Cardiac muscle The Lox Myofibroblast Oxidase Coronary circulation Rhesus macaque Lysyl oxidase Coronary artery disease Cytosol Protein Endothelium Cu Messenger RNA Ischemia Collagen Covalent bond Stiffness Infarction Catalysis Copper
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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