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Metallomics Vol - 8 Issue - 2

Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Cini, Melchior Fay, Mike W. Williams, Huw Woodward, Simon Bradshaw, Tracey D. Searle, Mark S.
Copyright Year	2016
Abstract	Tolerated by normal tissues, anti-cancer therapies based on titanium compounds are limited by low efficacy/selectivity and lack of understanding of their mode(s) of action. In vitro antitumour activity and mode of cell death incurred by enantiopure TiCl2{η-C5H4CHEt(2-MeOPh)}2 (abbreviated CpR2TiCl2) has been investigated. The in vitro anti-tumour activity of CpR2TiCl2 is selective for cancer cells; in clonogenic assays, (S,S)-CpR2TiCl2 was twice as effective at inhibiting colony formation than other stereoisomers after 24 h exposure. HPLC, MS and NMR techniques determined hydrolysis of CpR2TiCl2; data strongly correlate with soluble [CpR2Ti(OH)(OH2)]+ being the biological trigger. Treatment of cells with CpR2TiCl2 provoked extensive cytoplasmic vacuolization, endoplasmic reticulum (ER) swelling and activation of MAPKinase signal transduction, consistent with ligand-induced paraptosis, type III cell death, which is morphologically distinct from, and independent of apoptosis. Indeed, distinct from cisplatin, CpR2TiCl2 failed to perturb cell cycle dynamics, induce γH2AX foci or evoke apoptosis in MDA-MB-468 and HCT-116 cells.
Starting Page	286
Ending Page	297
Page Count	12
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	3
Journal	Metallomics
DOI	10.1039/c5mt00297d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA-MB-468 Ant colony High-performance liquid chromatography Vacuole Cisplatin Hydrolysis Signal transduction Enantiomer Cell cycle Titanium Nuclear magnetic resonance Endoplasmic reticulum Cancer Apoptosis NCI-60
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Correction: Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents

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Model mda-mb-468 open access.

Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis

Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells.

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Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

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Correction: Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents

Silencing of TGIF sensitizes MDA-MB-231 human breast cancer cells to cisplatin-induced apoptosis.

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Advances in Brief Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells 1

Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt. Cancer Res 2003;63:5470–9. Cancer Res 2006; 66

Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells