NDLI: Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress

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Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress

Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles

Correction: Understanding metal homeostasis in primary cultured neurons. Studies using single neuron subcellular and quantitative metallomics

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Metallomics Vol - 7 Issue - 8

Metallomics Vol - 7 Issue - 7

Metallomics Vol - 7 Issue - 6

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Metallomics Vol - 7 Issue - 4

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Metallomics Vol - 7 Issue - 2

Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress

Content Provider	Royal Society of Chemistry (RSC)
Author	Pacheco, Mário Brandão, Fátima Santos, Maria Ana Maisano, Maria Cappello, Tiziana Pereira, Patrícia Raimundo, Joana Mauceri, Angela
Copyright Year	2015
Abstract	Clarification of the mechanisms of mercury (Hg) toxicity in fish remains challenging. An innovative approach to this clarification is the combined assessment of metabolomic shifts, alterations in the antioxidant system and the risk of oxidative damage, and Hg bioaccumulation. This strategy was applied to the livers of golden grey mullet (Liza aurata) inhabiting an Hg-contaminated system in Aveiro Lagoon, Portugal. Marked changes in both the metabolic profile and the response to antioxidants were observed in fish exposed to Hg in the environment, indicating their compromised state of health. The metabolomics analysis showed a clear differentiation between the contaminated and uncontaminated areas, revealing that Hg has multiple levels of impact, including membrane stabilization/degradation/repair processes, osmoregulation, energy metabolism, gene expression and antioxidant protection. Research on oxidative stress biomarkers showed that Hg triggered adaptive responses in the antioxidant system as seen by an increase in the activities of glutathione-S-transferase and catalase, as well as the total glutathione content, which compensated for a decrease in glutathione peroxidase activity. The integration of metabolomics and oxidative stress endpoints allowed the identification of reduced glutathione as a first line of defence against Hg and evidenced oxidative insults in cell membranes, recognized through the increase in phosphatidylcholine degradation products (phosphocholine and glycerophosphocholine). Despite these effects, the induction of lipid peroxidation was efficiently prevented. The triad approach used here was demonstrated to be sensitive and effective towards a mechanistically based assessment of Hg hepatotoxicity in fish.
Starting Page	1352
Ending Page	1363
Page Count	12
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	7
Issue Number	9
Journal	Metallomics
DOI	10.1039/c5mt00090d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Liza Glutathione peroxidase Metabolomics Oxidative stress Flathead grey mullet Membrane stabilizing effect Osmoregulation Lipid peroxidation Antioxidant Metabolism Portugal Golden grey mullet Phosphocholine Gene Catalase Catalytic triad Bioaccumulation Alpha-GPC Methylmercury Phosphatidylcholine Glutathione S-transferase Aveiro Lagoon Hepatotoxicity Glutathione
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Age, Growth, and Sex Ratio of Golden Grey Mullet, Liza aurata (Risso, 1810) in Homa Lagoon (İzmir Bay, Aegean Sea)

Age, Growth, and Sex Ratio of Golden Grey Mullet, Liza aurata (Risso, 1810) in Homa Lagoon (İzmir Bay, Aegean Sea)

Biological monitoring of wild thicklip grey mullet (Chelon labrosus), golden grey mullet (Liza aurata), thinlip mullet (Liza ramada) and flathead mullet (Mugil cephalus) (Pisces: Mugilidae) from different Adriatic sites: meristic counts and skeletal anomalies

Toxicity of dispersant application: biomarkers responses in gills of juvenile golden grey mullet (Liza aurata)

Fisheries Management of the Thinlip Grey Mullet Liza Ram Ad a and Golden Grey Mullet Liza Aurata from Lake Bardawil, Egypt

First Isolation of Acinetobacter sp. from Golden grey mullet (Liza aurata) in Turkey

Organ specific antioxidant responses in golden grey mullet (Liza aurata) following a short-term exposure to phenanthrene.

Changes in Chloride Cell Abundance, Na+,K+-ATPase Immunolocalization and Activity in the Gills of Golden Grey Mullet, Liza Aurata, Fry During Adaptation to Differend Salinities

Toxicity of dispersant application: Biomarkers responses in gills of juvenile golden grey mullet (Liza aurata).

Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress

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Age, Growth, and Sex Ratio of Golden Grey Mullet, Liza aurata (Risso, 1810) in Homa Lagoon (İzmir Bay, Aegean Sea)

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Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress