NDLI: A microfluidic platform for integrated synthesis and dynamic light scattering measurement of block copolymer micelles

Content Provider	Royal Society of Chemistry (RSC)
Author	Chastek, Thomas Q. Beers, Kathryn L. Fasolka, Michael J. Iida, Kazunori Amis, Eric J.
Copyright Year	2008
Abstract	Microfluidic devices were developed that integrate the synthesis of well defined block copolymers and dynamic light scattering (DLS) measurement of their micelle formation. These metal devices were designed to operate in contact with organic solvents and elevated temperatures for long periods, and thus were capable of continuous in-channel atom transfer radical polymerization (ATRP) of styrene and (meth)acrylate homopolymers and block copolymers. These devices were equipped with a miniaturized fiber optic DLS probe that included several technology improvements, including a measurement volume of only 4 microlitres, simple alignment, and reduced multiple scattering. To demonstrate the integrated measurement, poly(methyl methacrylate-b-lauryl methacrylate) and poly(methyl methacrylate-b-octadecyl methacrylate) block copolymers were processed on the device with a selective solvent, dodecane, to induce micelle formation. The in situDLS measurements yielded the size and aggregation behavior of the micelles. For example, the block copolymer solutions formed discrete micelles (DH ≈ 25 nm) when the corona block was sufficiently long (fMMA < 0.51), but the micelles aggregated when this block was short. This study demonstrates the utility of these new devices for screening the solution behavior of custom synthesized polymeric surfactants and additives.
Starting Page	950
Ending Page	957
Page Count	8
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	8
Issue Number	6
Journal	Lab on a Chip
DOI	10.1039/b718235j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Atom-transfer radical-polymerization Dynamic light scattering Dodecane Acrylate Styrene Micelle Copolymer Solvent
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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