NDLI: Stop-flow lithography in a microfluidic device

Content Provider	Royal Society of Chemistry (RSC)
Author	Pregibon, Daniel C. Doyle, Patrick S. Dendukuri, Dhananjay Gu, Shelley S. Hatton, T. Alan
Copyright Year	2007
Abstract	Polymeric particles in custom designed geometries and with tunable chemical anisotropy are expected to enable a variety of new technologies in diverse areas such as photonics, diagnostics and functional materials. We present a simple, high throughput and high resolution microfluidic method to synthesize such polymeric particles. Building off earlier work that we have done on continuous flow lithography (CFL) (D. Dendukuri, D. C. Pregibon, J. Collins, T. A. Hatton, P. S. Doyle, Nat. Mater., 2006, 5, 365–369; ref. 1), we have devised and implemented a new setup that uses compressed air driven flows in preference to syringe pumps to synthesize particles using a technique that we call stop-flow lithography (SFL). A flowing stream of oligomer is stopped before polymerizing an array of particles into it, providing for much improved resolution over particles synthesized in flow. The formed particles are then flushed out at high flow rates before the cycle of stop-polymerize-flow is repeated. The high flow rates enable orders-of-magnitude improvements in particle throughput over CFL. However, the deformation of the PDMS elastomer due to the imposed pressure restricts how quickly the flow can be stopped before each polymerization event. We have developed a simple model that captures the dependence of the time required to stop the flow on geometric parameters such as the height, length and width of the microchannel, as well as on the externally imposed pressure. Further, we show that SFL proves to be superior to CFL even for the synthesis of chemically anisotropic particles with sharp interfaces between distinct sections.
Starting Page	818
Ending Page	828
Page Count	11
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	7
Issue Number	7
Journal	Lab on a Chip
DOI	10.1039/b703457a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Nat Dependent and independent variables Dendukuri Pregibon Elastomer CFL Polymerization Compact fluorescent lamp Oligomer Photonics Collins Hatton Doyle Anisotropy Photolithography
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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