NDLI: Steroid extraction in a microchannel system—mathematical modelling and experiments

Content Provider	Royal Society of Chemistry (RSC)
Author	Plazl, Igor Žnidaršič-Plazl, Polona
Copyright Year	2007
Abstract	The continuous ethyl acetate extraction of progesterone and 11α-hydroxyprogesterone, a reactant and the product of the biotransformation step involved in corticosteroid production, was studied in a microchannel at different flow velocities. In addition, non-steady state batch extraction without mixing was performed and modelled in order to verify the theoretically predicted parameters. In order to analyze experimental data and to forecast microreactor performance, a three-dimensional mathematical model with convection and diffusion terms was developed considering the velocity profile for laminar flow of two parallel phases in a microchannel at steady-state conditions. For the numerical solution of a complex equation system, non-equidistant finite differences were used. Very good agreement between model calculations and experimental data was achieved without any fitting procedure. Due to the efficient phase separation and high extraction yields obtained, the micro scale extraction units were found to be a promising tool for the development of an integrated system of 11α-hydroxylation of progesterone by Rhizopus nigricans in the form of pellets.
Starting Page	883
Ending Page	889
Page Count	7
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	7
Issue Number	7
Journal	Lab on a Chip
DOI	10.1039/b704432a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Corticosteroid Laminar flow Biotransformation Ethyl acetate Microreactor Progesterone Mathematical model Diffusion Convection 11α-Hydroxyprogesterone Black bread mold
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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