NDLI: Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

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Journal of Materials Chemistry B Vol - 5 Issue - 3

Journal of Materials Chemistry B Vol - 5 Issue - 2

Journal of Materials Chemistry B Vol -4

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Content Provider	Royal Society of Chemistry (RSC)
Author	Gan, Donglin Xu, Jielong Zhang, Hongping Wang, Zhixiong Wang, Kefeng Han, Lu Lu, Xiong Yuan, Huipin Weng, Jie
Copyright Year	2017
Abstract	Articular cartilage defect repair is challenging for clinics because of the lack of self-regenerative ability of avascular tissue. Gelatin-based hydrogels are widely used in the field of tissue engineering because of their good biodegradability, excellent biocompatibility, and cell/tissue affinity. However, gelatin-based hydrogels exhibit poor thermal stability and low mechanical strength, which limit their application in cartilage repair. In this study, methacrylic anhydride (MA) was employed to modify gelatin to obtain photo-crosslinkable methacrylated gelatin (GelMA). The GelMA-based natural–synthetic polymer biohybrid hydrogel was prepared by co-polymerizing acrylamide (AM) and GelMA under ultraviolet radiation in the presence of a photo-initiator. The GelMA/PAM biohybrid hydrogel simultaneously possessed the advantages of both PAM hydrogels and GelMA hydrogels. The GelMA block provided specific biological functions for cell adhesion and proliferation, while the flexible PAM chains reinforced the brittle gelatin network and sustained the load during deformation. Compared with pure PAM hydrogel and GelMA, the GelMA/PAM biohybrid hydrogels showed enhanced compression strength (0.38 MPa) and improved elasticity (storage modulus of 1000 Pa). The GelMA/PAM biohybrid hydrogel showed a favorable degradation rate and sustained protein release. In vitro cell culture showed that the chondrocytes remained viable and proliferated on the biohybrid hydrogel, demonstrating that the biohybrid hydrogels had good cell adhesion and excellent biocompatibility. In a rabbit knee cartilage defect model, we evaluated the cartilage repair ability of the biohybrid hydrogel in vivo. In summary, this study demonstrated that hybridization of synthetic polymers considerably improves the performance and expands the application of the gelatin-based hydrogels. The biohybrid hydrogel is a good candidate material to be applied in articular cartilage tissue engineering and may have great potential in various soft tissue engineering applications.
Starting Page	731
Ending Page	741
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	5
Issue Number	4
Journal	Journal of Materials Chemistry B
DOI	10.1039/c6tb02348g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cartilage Tissue engineering Biocompatibility Methacrylic anhydride Master's degree Gelatin Polymer Gel Acrylamide Amplitude modulation Ultraviolet Cell adhesion Protein Cell culture Hyaline cartilage
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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