NDLI: Honokiol nanoparticles stabilized by oligoethylene glycols codendrimer: <i>in vitro</i> and <i>in vivo</i> investigations

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhao, Shuang Han, Meihua Wang, Ting Qiu, Hanhong Wang, Xiangtao Zhao, Yanna Guo, Yifei
Copyright Year	2017
Abstract	Nanoparticles based on dendrimers were explored as excellent candidates for nanoscale drug delivery system. In this study, the fluorescently labeled amphiphilic codendrimer PGC from PAMAM G4.0 and oligoethylene glycol dendron was utilized as a carrier to prepare honokiol-loaded nanoparticles (HK NPs) via an evaporation method augmented by ultrasonication with an optimized drug-loading content (∼60%, wt%). The release of HK NPs showed a sustained release manner and was completed within 120 h. The HK NPs presented higher cytotoxicity against 4T1 cells, and the cellular uptake mechanism was proven to be caveolae-mediated endocytosis and clathrin-mediated endocytosis. Importantly, the HK NPs resulted in a strong antitumor efficacy on the 4T1 breast tumor model in vivo, and no significant adverse effects were observed. In addition, in vivo studies also showed that the HK NPs possessed better tumor accumulation over HCPT injection. According to the higher drug-loading content, enhanced antitumor efficacy, and appropriate particle size, HK NPs were shown to be safe and efficient drug delivery systems and could have potential application in cancer chemotherapy.
Starting Page	697
Ending Page	706
Page Count	10
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	5
Issue Number	4
Journal	Journal of Materials Chemistry B
DOI	10.1039/c6tb02416e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PGC HK NPs Drug delivery Amphiphile Cytotoxicity Endocytosis Cancer Chemotherapy
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells

Hydrophobic superparamagnetic FePt nanoparticles in hydrophilic poly(N-vinylcaprolactam) microgels: a new multifunctional hybrid system

A multi-stimuli responsive nanoparticulate SN38 prodrug for cancer chemotherapy

Overview on in vitro and in vivo investigations of nanocomposite based cancer diagnosis and therapeutics

In vitro cellular uptake and cytotoxicity of paclitaxel-loaded glycol chitosan self-assembled nanoparticles

Honokiol nanoparticles stabilized by oligoethylene glycols codendrimer: in vitro and in vivo investigations

Similar Documents

In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells

Hydrophobic superparamagnetic FePt nanoparticles in hydrophilic poly(N-vinylcaprolactam) microgels: a new multifunctional hybrid system

A multi-stimuli responsive nanoparticulate SN38 prodrug for cancer chemotherapy

Overview on in vitro and in vivo investigations of nanocomposite based cancer diagnosis and therapeutics

In vitro cellular uptake and cytotoxicity of paclitaxel-loaded glycol chitosan self-assembled nanoparticles

Honokiol nanoparticles stabilized by oligoethylene glycols codendrimer: in vitro and in vivo investigations