NDLI: Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

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Journal of Materials Chemistry B Vol - 5 Issue - 2

Journal of Materials Chemistry B Vol -4

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Neodymium-doped NaHoF₄ nanoparticles as near-infrared luminescent/T₂-weighted MR dual-modal imaging agents in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Qiangbin Shi, Liyi Li, Yanfang Li, Fujin Zhang, Yanhui Feng, Yamin Lin, Hongzhen Xiao, Qingbo Li, Chunyan
Copyright Year	2017
Abstract	The achievement of efficient near-infrared (NIR) luminescence of lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance of multimodal bioprobes. Herein, we present a facile coprecipitation method to prepare highly uniform NaHoF4:Nd3+ nanoplates. Upon NIR excitation at 785 nm, efficient NIR luminescence of Nd3+ can be obtained from the paramagnetic NaHoF4 hosts. More interestingly, due to energy transfer from the excited state of Nd3+ to the adjacent Ho3+, NIR emission at around 1200 nm from Ho3+ ions is also observed. The r2 value of NaHoF4:Nd3+ NPs reaches 143.7 s−1 mM−1 at a high magnetic field of 11.7 T. By modifying with hydrophilic alpha-cyclodextrin, the NaHoF4:Nd3+ NPs were further successfully applied for the NIR luminescent/T2-weighted MR dual-modal in vivo imaging of nude mice, high contrast NIR imaging of the liver and T2-weighted MR imaging of stem cells in the mouse brain using the NaHoF4:Nd3+ NPs as multimodal bioprobes.
Starting Page	504
Ending Page	510
Page Count	7
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	5
Issue Number	3
Journal	Journal of Materials Chemistry B
DOI	10.1039/c6tb01961g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	NP NIR Luminescence Lanthanide Paramagnetism Nanoparticle Coprecipitation Magnetic field Hydrophile Magnetic resonance imaging Nude mouse High Contrast Liver Laboratory mouse
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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