NDLI: A patterned porous polymer film for localized capture of insulin and glucose-responsive release

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Back cover

Journal of Materials Chemistry B Vol - 3 Issue - 6

Journal of Materials Chemistry B Vol - 3 Issue - 5

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

A patterned porous polymer film for localized capture of insulin and glucose-responsive release

Content Provider	Royal Society of Chemistry (RSC)
Author	Sims, Savannah Wu, Lixin Liang, Jing Ma, Yingyi
Copyright Year	2015
Abstract	A glucose-responsive, porous polymer film which can be used for controlled insulin release was fabricated. By mixing a polystyrene–dichloromethane solution containing didodecylamine with water, with thorough shaking, a reverse microemulsion was achieved. After spreading the microemulsion on a glass slide and evaporating the solvent, an ordered honeycomb-patterned film was produced, accompanied by an accumulation of didodecylamine within the inner surface of the cavities. The patterned cavities were further modified with poly(acrylic acid), 3-aminophenylboronic acid, and alginate so that they would entrap insulin aggregates. The insulin aggregates were prepared using a salting-out method and were incorporated into the cavities by an electrostatic interaction with the alginate. Under the stimulus of glucose, insulin aggregates were released from the cavities and further calculations demonstrated that there was a very high efficiency of release. In contrast, in an aqueous solution without glucose, almost no insulin was released from the cavities. This investigation demonstrates that it is feasible for porous polymer films, whose cavities act as a protein reservoir, to be used as a glucose-responsive insulin delivery vehicle, which may have potential as a controlled-release drug-delivery system for the treatment of diabetes.
Starting Page	1281
Ending Page	1288
Page Count	8
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	3
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c4tb01537a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Polymer Insulin Microemulsion Solvent Acid Alginic acid Salting out Glucose Protein Petroleum reservoir Delivery (commerce) Diabetes mellitus
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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