NDLI: Nanoassemblies of Gd–DTPA–monooleyl and glycerol monooleate amphiphiles as potential MRI contrast agents

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Journal of Materials Chemistry B Vol - 2 Issue - 8

Journal of Materials Chemistry B Vol - 2 Issue - 7

Journal of Materials Chemistry B Vol - 2 Issue - 6

Journal of Materials Chemistry B Vol - 2 Issue - 5

Journal of Materials Chemistry B Vol -1

Nanoassemblies of Gd–DTPA–monooleyl and glycerol monooleate amphiphiles as potential MRI contrast agents

Content Provider	Royal Society of Chemistry (RSC)
Author	Gupta, Abhishek Campo, Liliana de Kirby, Nigel Stait-Gardner, Timothy Waddington, Lynne J. Moghaddam, Minoo J. Price, William S.
Copyright Year	2014
Abstract	Self-assembly of lipid-based amphiphiles into various supramolecular nanostructured particles has been used in creating novel nanomaterials with diverse applications in drug delivery and diagnostic imaging. Here we report on Gd(III) chelated DTPA amphiphiles with an oleyl chain (Gd–DTPA–MO) incorporated within the self-assembly matrix of glycerol monooleate (GMO), an inverse cubic phase forming system, at varying compositions. The dispersed colloidal nanoassemblies were explored for their potential as magnetic resonance imaging (MRI) contrast agents. We investigated the homogeneity of the mixed amphiphiles in bulk phases by differential scanning calorimetry (DSC) and their lyotropic phase behaviour by synchrotron small angle X-ray scattering (SAXS). The liquid crystalline nanostructures, morphology and the size distribution of the nanoassemblies were studied by synchrotron SAXS, cryogenic transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS). SAXS and cryo-TEM results revealed the formation of inverse cubosomes in dispersions with ≤1 mol% of Gd–DTPA–MO, and liposomal and rod-shaped micellar aggregates with >1 mol%. The stability of cubosomal nanoassemblies was assessed in the presence of fetal bovine serum, showing minimal effect on their nanostructures. In vitro relaxivity studies were performed at four different magnetic field strengths (0.54, 7.05, 9.40 and 11.74 T). All the colloidal dispersions displayed enhanced longitudinal relaxivities per Gd over Magnevist, a commercially available contrast agent, at both low and high magnetic field strengths. In addition, cubosomes with 3D-periodic interior nanostructures, extensive water channels and high interfacial surface area, showed promise as high field contrast agents. These stable colloidal particles also have potential to be used as combined delivery matrices for diagnostics and therapeutics (theranostics).
Starting Page	1225
Ending Page	1233
Page Count	9
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	2
Issue Number	9
Journal	Journal of Materials Chemistry B
DOI	10.1039/c3tb21069c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DSC Nanomaterials Drug delivery Pentetic acid Self-assembly Extracellular matrix Glycerol Magnetic resonance imaging Differential scanning calorimetry Lyotropic liquid crystal Synchrotron Small-angle X-ray scattering Cryogenic transmission electron microscopy Dynamic light scattering Bacillus Micelle Fetal bovine serum Magnetic field Gadopentetic acid Contrast medium
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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