NDLI: Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy

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Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy

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Biomaterials Science Vol - 2 Issue - 5

Biomaterials Science Vol - 2 Issue - 4

Biomaterials Science Vol - 2 Issue - 3

Biomaterials Science Vol - 2 Issue - 2

Biomaterials Science Vol -1

Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Bean, Penny A. Campo, Liliana de Scoble, Judith A. Moghaddam, Minoo J. Waddington, Lynne J. Drummond, Calum J. Coia, Gregory Hirabayashi, Mioko
Copyright Year	2014
Abstract	Engineering biocompatible and physiologically stable nanoscaled therapeutics and imaging agents with the ability to target tumor tissue is a key challenge for the advancement of cancer therapeutics and diagnostic imaging. Here, we present chelating amphiphiles with the capacity to form nanoassembled colloidal particles containing high payloads of gadolinium (Gd) ions. We present the in situ synthesis and complexation of Gd with colloidal nanoassemblies (NAs) based on diethylenetriamine pentaacetic acid (DTPA) amphiphiles. This method allows for facile simultaneous incorporation of several metal ions for applications in multimodal imaging and therapeutics. The diverse internally nanostructured NAs made from sole precursor amphiphiles and their Gd-complexes were investigated by synchrotron small angle X-ray scattering (SAXS) and cryo-TEM. Depending on the molecular structure of the amphiphiles, the structures of NAs range from micelles to liposomes, to colloidal particles of inverse hexagonal (hexosomes) and inverse bicontinuous cubic phases (cubosomes), to multilayered nanospheres. The in vitro contrast activity of these NAs exhibited high relaxivity values as T1-weighted magnetic resonance imaging (MRI) contrast enhancement agents. Further, an α-Flag antibody fragment (Fab′) was bioconjugated to the surface of the Gd-complexed NAs. The binding ability of these targeted NAs to a FLAG-tagged protein was confirmed by SDS-PAGE. The in vitro cytotoxicity against two cell lines showed that except for the negatively charged micellar Gd-DTPA amphiphile, liposomal and higher order internally nanostructured NAs had low cell toxicity. The efficient cellular uptake of Gd-NAs by melanoma cancer cells was also investigated.
Starting Page	924
Ending Page	935
Page Count	12
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	2
Issue Number	6
Journal	Biomaterials Science
DOI	10.1039/c3bm60235d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Polyacrylamide gel electrophoresis Acid Melanoma Micelle Gadolinium Cytotoxicity Protein Small-angle X-ray scattering Pentetic acid Diethylenetriamine Magnetic resonance imaging Biocompatibility Amphiphile Synchrotron radiation Cancer
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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