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Antibacterial properties and bioactivity of HACC- and HACC–Zein-modified mesoporous bioactive glass scaffolds

Content Provider	Royal Society of Chemistry (RSC)
Author	Yu, Long Tang, Wei Xu, Shuogui Zhou, Panyu Xia, Yan Gu, Shen Wang, Jing Liang, Chong
Copyright Year	2013
Abstract	Infection and its complications are one of the greatest threats to the health of orthopedic patients. Mesoporous bioglass (MBG) scaffolds are characterized by well-ordered, three-dimensional, nanometer-sized mesoporous structures, which facilitate the adhesion of hydroxyapatite and the loading of drugs. MBG has been widely used as a new-generation biomaterial in bone tissue engineering. However, MBG is very brittle and lacks antibacterial activity. This limits its applications in the treatment of bone defects, especially large bone defects complicated by infection. In order to dispel these disadvantages, a novel hydroxypropyltrimethyl ammonium chloride chitosan (HACC) and a class of prolamine proteins found in maize, Zeins, were here used to modify the traditional MBG scaffolds. Two new types of scaffold, MBG–HACC scaffolds and MBG–HACC–Zein scaffolds, were made. Transmission electron microscopy (TEM), small angle X-ray diffraction (SAXRD), and Barrett–Joyner–Halenda (BJH) were used to analyze the surface properties of these MBG scaffolds. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), mechanical experiments, and synchrotron radiation microcomputer tomography (SRμCT) were used to compare the features of the traditional and modified scaffolds and to analyze the mineralization of the scaffold after being soaked in simulated body fluid (SBF). Confocal laser scanning microscopy (CLSM) was used to compare the antibacterial properties and biocompatibility of the scaffolds at various points in time. The current study demonstrates that all these prepared MBG scaffolds possessed well-ordered, three-dimensional, nanometer-sized mesoporous structures and that HACC–Zein-modified MBG scaffolds are characterized by strong bioactivity and by effective, prolonged antibacterial activity. Finally, biocompatibility was demonstrated by studying the in vitro proliferation and viability of human mesenchymal stem cells (hMSCs).
Starting Page	685
Ending Page	692
Page Count	8
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	1
Issue Number	5
Journal	Journal of Materials Chemistry B
DOI	10.1039/c2tb00102k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Zein Barrett Joyner Fourier Zeins Bioglass Mesoporous material Hydroxylapatite Biomaterial Bone Tissue engineering Ammonium chloride Chitosan Prolamin Maize Transmission electron microscopy X-ray crystallography Infrared spectroscopy Scanning electron microscope Synchrotron Microcomputer Simulated body fluid Confocal microscopy Biocompatibility Mesenchymal stem cell
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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