NDLI: Chemical characterisation and fabrication of chitosan–silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane

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Front cover

Contents list

Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications

Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Promoting cell adhesion on slippery phosphorylcholine hydrogel surfaces

A novel aptameric nanobiosensor based on the self-assembled DNA–MoS₂ nanosheet architecture for biomolecule detection

Self-focusing Au@SiO₂ nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection

Synthesis of boronic acid-functionalized molecularly imprinted silica nanoparticles for glycoprotein recognition and enrichment

Chemically tunable cationic polymer-bonded magnetic nanoparticles for gene magnetofection

Stimuli-responsive electrospun nanofibers from poly(N-isopropylacrylamide)-co-poly(acrylic acid) copolymer and polyurethane

Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and α-cyclodextrin

Chemical characterisation and fabrication of chitosan–silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane

Polyurethane/β-cyclodextrin/ciprofloxacin composite films for possible medical coatings with antibacterial properties

A silicon-based antibacterial material featuring robust and high antibacterial activity

Swarming carbon dots for folic acid mediated delivery of doxorubicin and biological imaging

The fabrication and characterization of Cu-nanoparticle immobilization on a hybrid chitosan derivative-carbon support as a novel electrochemical sensor: application for the sensitive enzymeless oxidation of glucose and reduction of hydrogen peroxide

Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing

Preparation of core–shell Fe₃O₄@poly(dopamine) magnetic nanoparticles for biosensor construction

Back cover

Journal of Materials Chemistry B Vol - 2 Issue - 5

Journal of Materials Chemistry B Vol -1

Chemical characterisation and fabrication of chitosan–silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane

Content Provider	Royal Society of Chemistry (RSC)
Author	Romer, Frederik Jones, Julian R. Lee, Peter D. Suárez, Marta Connell, Louise S. Smith, Mark E. Valliant, Esther M. Zhang, Ziyu Hanna, John V.
Copyright Year	2014
Abstract	Chitosan has been explored as a potential component of biomaterials and scaffolds for many tissue engineering applications. Hybrid materials, where organic and inorganic networks interpenetrate at the molecular level, have been a particular focus of interest using 3-glycidoxypropyl trimethoxysilane (GPTMS) as a covalent crosslinker between the networks in a sol–gel process. GPTMS contains both an epoxide ring that can undergo a ring opening reaction with the primary amine of chitosan and a trimethoxysilane group that can co-condense with silica precursors to form a silica network. While many researchers have exploited this ring-opening reaction, it is not yet fully understood and thus the final product is still a matter of some dispute. Here, a detailed study of the reaction of GPTMS with chitosan under different pH conditions was carried out using a combination of solution state and solid state MAS NMR techniques. The reaction of GPTMS with chitosan at the primary amine to form a secondary amine was confirmed and the rate was found to increase at lower pH. However, a side-reaction was identified between GPTMS and water producing a diol species. The relative amounts of diol and chitosan–GPTMS species were 80 and 20% respectively and this ratio did not vary with pH. The functionalisation pH had an effect on the mechanical properties of 65 wt% organic monoliths where the properties of the organic component became more dominant. Scaffolds were fabricated by freeze drying and had pore diameters in excess of 140 μm, and tailorable by altering freezing temperature, which were suitable for tissue engineering applications. In both monoliths and scaffolds, increasing the organic content disrupted the inorganic network, leading to an increase in silica dissolution in SBF. However, the dissolution of silica and chitosan was congruent up to 4 weeks in SBF, illustrating the true hybrid nature resulting from covalent bonding between the networks.
Starting Page	668
Ending Page	680
Page Count	13
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	2
Issue Number	6
Journal	Journal of Materials Chemistry B
DOI	10.1039/c3tb21507e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chitosan SBF Biomaterial Tissue engineering Covalent bond Sol\u2013gel process Epoxide Silicon dioxide Cyclic compound PH Magic angle spinning Nuclear magnetic resonance Amine Diol Freeze-drying Micrometre
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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