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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Yu, Chengzhong Jia, Zhongfan Hartono, Sandy Budi Monteiro, Michael J. Phuoc, Nghia Truong Yu, Meihua Qiao, Shizhang |
| Copyright Year | 2014 |
| Abstract | Novel mesoporous silica nanoparticles (LPMSNs) functionalised with degradable poly(2-dimethylaminoethyl acrylate) (PDMAEA) have been developed (PDMAEA–LPMSNs) as nano-carriers for gene delivery. The unique design of PDMAEA–LPMSNs has endowed this system with multiple functions derived from both the organic and inorganic moieties. The cationic polymer unit binds to genetic molecules and undergoes a self-catalyzed hydrolysis in water to form a non-toxic anionic polymer poly(acrylic acid), allowing controlled release of siRNA in the cells. The nanopores of the LPMSNs provide a reservoir for storage and release of chloroquine to facilitate endosomal escape. The PDMAEA–LPMSN composites were characterized by elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), solid-state 13C magic-angle spinning nuclear magnetic resonance (MAS-NMR), thermogravimetric analysis (TGA), and nitrogen sorption techniques. Their siRNA delivery performance was tested in a KHOS cell line, showing promising potential for co-delivery of genes and drugs. |
| Starting Page | 718 |
| Ending Page | 726 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 2 |
| Issue Number | 6 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c3tb21015d |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Mesoporous silica Acrylate Gene Polymer Hydrolysis Carboxylic acid Small interfering RNA Petroleum reservoir Chloroquine X-ray photoelectron spectroscopy Photoemission spectroscopy Nuclear magnetic resonance Thermogravimetric analysis Nitrogen Sorption |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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