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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Delcea, Mihaela Palankar, Raghavendra Skirtach, André G. Fery, Andreas Schmidt, Stephan Geest, Bruno G. De Möhwald, Helmuth Pinchasik, Bat-El |
| Copyright Year | 2013 |
| Abstract | Developing carriers comprised of biomaterials and capable of withstanding significant mechanical pressures, structural deformations and at the same time delivering biomolecules is of high interest for drug delivery. Using colloidal probe AFM combined with quantitative fluorescence microscopy, we investigated mechanical properties and release from CaCO3-templated polymeric capsules made of biodegradable polymers. The mechanical and release properties of these capsules were studied in comparison with those of CaCO3-templated capsules composed of synthetic polymers. Furthermore, we assessed the influence of the number of polyelectrolyte LbL layers on the mechanical properties and release from biodegradable capsules. Mechanical deformation of capsules was studied upon intracellular uptake of these capsules. Based on these results, we discuss implications for the design of microcapsules. |
| Starting Page | 1175 |
| Ending Page | 1181 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 1 |
| Issue Number | 8 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c2tb00319h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Biomaterial Drug delivery Biodegradation Polyelectrolyte |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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