NDLI: Aluminium uptake and excretion in potroom workers of a new primary aluminium smelter during the construction stage

Content Provider	Royal Society of Chemistry (RSC)
Author	Nogueira, Claudina M. C. A. Röllin, Halina B. Theodorou, Penelope Levin, Jonathan
Copyright Year	2001
Abstract	The aim of this study was to define bio-accumulation and excretion patterns of aluminium in newly employed potroom workers as well as changes in ambient aluminium levels in the potrooms of a modern aluminium smelter during the plant construction stage and one year into full production. A study was carried out on 115 newly employed volunteer potroom workers at various intervals, over a total period of 36 months. Before commencement of employment a structured questionnaire was completed by all study participants and the first collection of blood and urine specimens took place. As none of the subjects had ever worked in the aluminium industry before, they also served as their own controls. Atomic absorption spectroscopy was used to measure the aluminium content in the biological fluids and the content of the metal in the ambient air of the potrooms. Significantly, the study found an early and marked biological response to inhalation of very low levels of airborne aluminium. After only 12 months, the mean concentration of aluminium in serum had almost doubled; thereafter it levelled off. A mixed model analysis did not find any differences in the concentrations of aluminium in the serum of the subjects since the variation between subjects at any given time was much smaller than the variation within subjects. This may be an indication of the pronounced effect of aluminium inhalation on the kinetics of this metal in the human body. Furthermore, urinary excretion of aluminium by the potroom workers showed a linear increase reaching a concentration of only 49 µg l−1 at the 36 month stage, suggesting a slow rate of elimination.
Starting Page	560
Ending Page	564
Page Count	5
File Format	HTM / HTML PDF
ISSN	14640325
Volume Number	3
Issue Number	6
Journal	Journal of Environmental Monitoring
DOI	10.1039/b105849p
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Aluminium Urine Atomic absorption spectroscopy Particulates Mixed model
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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