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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Mokantla, Ernest Duncan, Neil McCrindle, Cheryl M. E. |
| Copyright Year | 2001 |
| Abstract | Animals may act as bioindicators for potential human health problems associated with mining and refining. Eight cattle died after a vanadium mine dam collapsed close to the area in which they were grazing. Necropsies were conducted on five cattle. Affected animals had shown a watery bloody diarrhea, red urine and listlessness before collapsing. On necropsy (n = 5) there was a moderate bilateral multifocal granulomatous-like conjunctivitis. The most prominent lesions were eosinophillic granulomatous-like inflammation of the thymus, mediastinal and mesenteric lymphnodes, oesophagus, abomasum and colon. There was also marked hyperaemia of the abomasal mucosa with petechiation. Pulmonary and tracheal haemorrhage was also present. Histopathology showed severe inflammatory cell infiltration (mainly eosinophils with lesser numbers of neutrophils and macrophages) of lymphoid tissue associated with the thymus, lymph nodes, esophagus, abomasum, colon and conjunctiva. There were also areas of tissue necrosis, congested blood vessels and haemorrhage. Conjunctival lesions point to a systemic rather than a local effect as the cattle in this case died following ingestion rather than inhalation of vanadium. The causal relationship between intoxication and death is conventionally based on the level of that toxin present in tissues at necropsy. The variability in demonstrating vanadium in biological samples may have been due to the rapid excretion of vanadium by the living animal, or the solubility of the salts, which results in the substance leaching into the fluid portion of the samples. Cross-reactions with colorimetric tests for arsenic should also be noted. |
| Starting Page | 580 |
| Ending Page | 582 |
| Page Count | 3 |
| File Format | HTM / HTML PDF |
| ISSN | 14640325 |
| Volume Number | 3 |
| Issue Number | 6 |
| Journal | Journal of Environmental Monitoring |
| DOI | 10.1039/b107244g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Vanadium Dam Autopsy Diarrhea Urine Conjunctivitis Inflammation Thymus Mediastinum Mesentery Esophagus Abomasum Large intestine Hyperaemia Mucous membrane Bleeding Eosinophil Neutrophil Macrophage Lymphatic system Lymph node Conjunctiva Necrosis Arsenic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law |
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