NDLI: Oxygen-18 stable isotope of exhaled breath CO<sub>2</sub> as a non-invasive marker of <i>Helicobacter pylori</i> infection

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Oxygen-18 stable isotope of exhaled breath CO₂ as a non-invasive marker of Helicobacter pylori infection

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Oxygen-18 stable isotope of exhaled breath CO₂ as a non-invasive marker of Helicobacter pylori infection

Content Provider	Royal Society of Chemistry (RSC)
Author	Som, Suman Pradhan, Manik Chaudhuri, Sujit Maity, Abhijit Daschakraborty, Sunil B. Ghosh, Chiranjit Banik, Gourab Dutta Ghosh, Shibendu
Copyright Year	2014
Abstract	We report for the first time the time-dependent excretion kinetics of 18O/16O isotope ratios of CO2 in exhaled breath samples using an optical cavity-enhanced integrated cavity output spectroscopy (ICOS) method for the detection of Helicobacter pylori (H. pylori) infection in human stomach. We observed large differences in the oxygen-18 isotopic fractionations of breath CO2 between H. pylori positive and negative individuals in response to orally administered, both unlabelled and labelled 13C-enriched urea, suggesting a potential link between H. pylori infections and the 18O-isotopic exchange in exhaled breath. An optimal diagnostic cut-off point of 18O/16O isotope ratios of breath CO2 for the presence of H. pylori infection was determined to be 1.92‰ using the receiver operating characteristic curve (ROC) analysis, which exhibited both diagnostic sensitivity and specificity of 100% with an accuracy of 100%. Moreover, the methodology of monitoring 18O in breath CO2 manifested both positive and negative predictive values of 100%, demonstrating excellent diagnostic accuracy and suggesting that breath C18O16O could be used as a potential marker for the identification of H. pylori infections. Our findings also suggest that monitoring the 18O/16O isotope ratios of breath CO2 is a valid and sufficiently robust novel non-invasive approach for the accurate and specific detection of H. pylori infection in real-time, which may open new perspectives in the molecular diagnosis of H. pylori infection for large-scale screening purposes, early detection and follow-up of patients.
Starting Page	2251
Ending Page	2255
Page Count	5
File Format	HTM / HTML PDF
ISSN	02679477
Volume Number	29
Issue Number	12
Journal	Journal of Analytical Atomic Spectrometry
DOI	10.1039/c4ja00280f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	ICOS pylori ROC Oxygen-18 Isotope Spectroscopy Icos Helicobacter pylori Isotope fractionation Urea Receiver operating characteristic
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Analytical Chemistry

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Oxygen-18 stable isotope of exhaled breath CO2 as a non-invasive marker of Helicobacter pylori infection

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Oxygen-18 stable isotope of exhaled breath CO₂ as a non-invasive marker of Helicobacter pylori infection

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