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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Mandal, Parthasarathi O'Connor, Joseph Revell, Alistair Day, Philip |
| Copyright Year | 2016 |
| Abstract | Patient-specific simulations, efficient parametric analyses, and the study of complex processes that are otherwise experimentally intractable are facilitated through the use of Computational Fluid Dynamics (CFD) to study biological flows. This review discusses various CFD methodologies that have been applied across different biological scales, from cell to organ level. Through this discussion the lattice Boltzmann method (LBM) is highlighted as an emerging technique capable of efficiently simulating fluid problems across the midrange of scales; providing a practical analytical tool compared to methods more attuned to the extremities of scale. Furthermore, the merits of the LBM are highlighted through examples of previous applications and suggestions for future research are made. The review focusses on applications in the midrange bracket, such as cell–cell interactions, the microcirculation, and microfluidic devices; wherein the inherent mesoscale nature of the LBM renders it well suited to the incorporation of fluid–structure interaction effects, molecular/particle interactions and interfacial dynamics. The review demonstrates that the LBM has the potential to become a valuable tool across a range of emerging areas in bio-CFD, such as understanding and predicting disease, designing lab-on-a-chip devices, and elucidating complex biological processes. |
| Starting Page | 589 |
| Ending Page | 602 |
| Page Count | 14 |
| File Format | HTM / HTML PDF |
| ISSN | 17579694 |
| Volume Number | 8 |
| Issue Number | 5 |
| Journal | Integrative Biology |
| DOI | 10.1039/c6ib00009f |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Computational Fluid Dynamics LBM Computational fluid dynamics Crystal structure Mesoscopic physics Lab-on-a-chip |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Biophysics |
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