NDLI: Self-assembly of vascularized tissue to support tumor explants <i>in vitro</i>

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Investigation of the adhesive characteristics of polymer–protein systems through molecular dynamics simulation and their relation to cell adhesion and proliferation

Modulating the microtubule–tau interactions in biomotility systems by altering the chemical environment

Self-assembly of vascularized tissue to support tumor explants in vitro

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Integrative Biology Vol - 8 Issue - 9

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Self-assembly of vascularized tissue to support tumor explants in vitro

Content Provider	Royal Society of Chemistry (RSC)
Author	Bazou, Despina Munn, Lance L. Maimon, Nir Gruionu, Gabriel
Copyright Year	2016
Abstract	Testing the efficacy of cancer drugs requires functional assays that recapitulate the cell populations, anatomy and biological responses of human tumors. Although current animal models and in vitro cell culture platforms are informative, they have significant shortcomings. Mouse models can reproduce tissue-level and systemic responses to tumor growth and treatments observed in humans, but xenografts from patients often do not grow, or require months to develop. On the other hand, current in vitro assays are useful for studying the molecular bases of tumorigenesis or drug activity, but often lack the appropriate in vivo cell heterogeneity and natural microenvironment. Therefore, there is a need for novel tools that allow rapid analysis of patient-derived tumors in a robust and representative microenvironment. We have developed methodology for maintaining harvested tumor tissue in vitro by placing them in a support bed with self-assembled stroma and vasculature. The harvested biopsy or tumor explant integrates with the stromal bed and vasculature, providing the correct extracellular matrix (collagen I, IV, fibronectin), associated stromal cells, and a lumenized vessel network. Our system provides a new tool that will allow ex vivo drug-screening and can be adapted for the guidance of patient-specific therapeutic strategies.
Starting Page	1301
Ending Page	1311
Page Count	11
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	8
Issue Number	12
Journal	Integrative Biology
DOI	10.1039/c6ib00108d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cancer Anatomy Cell culture Carcinogenesis Stromal cell Biopsy Extracellular matrix Type I collagen Fibronectin
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Self-assembly of vascularized tissue to support tumor explants in vitro

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