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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Kim, Song Cheol Hwang, Woonbong Kim, Yeongae Park, Jaesung Lee, Sangmin Cho, Siwoo Jeong, Seong Hee |
| Copyright Year | 2013 |
| Abstract | Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O2. The extracorporeal encapsulation system composed of these membranes allows O2 flux to meet the O2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets. |
| Starting Page | 828 |
| Ending Page | 834 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 17579694 |
| Volume Number | 5 |
| Issue Number | 5 |
| Journal | Integrative Biology |
| DOI | 10.1039/c3ib20226g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Langerhans Oxygen Semipermeable membrane Immunoisolate Porosity Geometry Aluminium oxide Polyethylene glycol Self-assembly Glucose Insulin Extracorporeal Pancreatic islets |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Biophysics |
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