NDLI: Conserved host–pathogen PPIsGlobally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds

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Conserved host–pathogen PPIsGlobally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds

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Integrative Biology Vol - 5 Issue - 2

Integrative Biology Vol -4

Integrative Biology Vol -3

Integrative Biology Vol -2

Integrative Biology Vol -1

Conserved host–pathogen PPIsGlobally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds

Content Provider	Royal Society of Chemistry (RSC)
Author	Barve, Neha León-Sicairos, Nidia Rahangdale, Sachin Devarapalli, Pratap Gupta, Krishnakant Blum, Kenneth Khatri, Gourav Tiwari, Sandeep Miyoshi, Anderson Misra, Amarendra Narayan Canizalez-Roman, Adrian Ali, Amjad Kumavath, Ranjith Ghosh, Preetam Silva, Artur Hassan, Syed Shah Bakhtiar, Marriam Azevedo, Vasco Baumbach, Jan Jain, Neha Guimarães, Luis Carlos Ramos, Rommel Thiago Jucá Verma, Ankit Barh, Debmalya Kumar, Anil Santos, Anderson Rodrigues dos
Copyright Year	2013
Abstract	Although attempts have been made to unveil protein–protein and host–pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to develop common conserved intra-species protein–protein interaction (PPI) networks first time for four Cp strains (Cp FRC41, Cp 316, Cp 3/99-5, and Cp P54B96) followed by development of a common conserved inter-species bacterial PPI using conserved proteins in multiple pathogens (Y. pestis, M. tuberculosis, C. diphtheriae, C. ulcerans, E. coli, and all four Cp strains) and E. Coli based experimentally validated PPI data. Furthermore, the interacting proteins in the common conserved inter-species bacterial PPI were used to generate a conserved host–pathogen interaction (HP-PPI) network considering human, goat, sheep, bovine, and horse as hosts. The HP-PPI network was validated, and acetate kinase (Ack) was identified as a novel broad spectrum target. Ceftiofur, penicillin, and two natural compounds derived from Piper betel were predicted to inhibit Ack activity. One of these Piper betel compounds found to inhibit E. coli O157:H7 growth similar to penicillin. The target specificity of these betel compounds, their effects on other studied pathogens, and other in silico results are currently being validated and the results are promising.
Starting Page	495
Ending Page	509
Page Count	15
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	5
Issue Number	3
Journal	Integrative Biology
DOI	10.1039/c2ib20206a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CLA Piper Caseous Lymphadenitis Coli Corynebacterium Theoretical ecology Lymphadenopathy Protein\u2013protein interaction Mycobacterium tuberculosis Escherichia coli Host\u2013pathogen interaction Goat Acetate kinase Ceftiofur Penicillin Betel
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

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Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis—General Aspects

Potential in vitro action of an adenosine analog and synergism with penicillin against Corynebacterium pseudotuberculosis.

Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease

CASEOUS LYMPHADENITIS: EPIDEMIOLOGY, DIAGNOSIS, AND CONTROL

Chapter 2 Corynebacterium diphtheriae , Corynebacterium ulcerans and Corynebacterium pseudotuberculosis — General Aspects

Antimicrobial Susceptibility of Corynebacterium pseudotuberculosis Isolated from Lesions of Caseous Lymphadenitis in Sheep in Hokkaido, Japan

Występowanie i chorobotwórczość dla człowieka potencjalnie toksynotwórczych maczugowców - Corynebacterium diphtheriae, Corynebacterium ulcerans i Corynebacterium pseudotuberculosis

Transformation of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and Escherichia coli with the C. diphtheriae plasmid pNG2.

The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis

Conserved host–pathogen PPIsGlobally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds

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Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis—General Aspects

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