NDLI: Lesser <i>in vitro</i> anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters

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Lesser in vitro anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters

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Food & Function Vol - 2 Issue - 3-4

Food & Function Vol - 2 Issue - 2

Food & Function Vol -1

Lesser in vitro anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters

Content Provider	Royal Society of Chemistry (RSC)
Author	Hendrich, Suzanne Renouf, Mathieu
Copyright Year	2011
Abstract	Our hypothesis in this study was that in vitro disappearance of isoflavones from fecal or cecal contents of Golden Syrian hamsters paralleled the apparent absorption of these compounds, comparable with previous findings from in vitro human fecal incubations. Two studies were conducted to test this idea: one on in vitro fecal (study 1, n = 20/sex) and the other on in vitro cecal contents (study 2, n = 10/sex) ability to degrade isoflavones. According to HPLC analysis, urinary isoflavone excretion was significantly less by 2–4 fold in males compared with females in both studies. Fecal isoflavone excretion was not significantly different between sexes or isoflavones (study 1) and was <0.5% of ingested dose. In vitro anaerobic fecal isoflavone degradation rate constants from study 1 were minimal with no significant correlation between urinary and fecal isoflavone excretion. However, in vitro anaerobic cecal isoflavone degradation rate constants (study 2) were greater and significantly correlated with urinary excretion of daidzein (R = 0.90; p = 0.01) and genistein (R = 0.93; p = 0.004), but not glycitein (R = 0.50; p = 0.3). Both male and female hamsters showed a pattern of urinary isoflavone excretion similar to that found in humans (daidzein > genistein). Hamster in vitro cecal isoflavone degradation rate constants seemed to be analogous to human in vitro fecal isoflavone degradation rate constants for genistein and daidzein. The sex difference in isoflavone excretion in hamsters and the instability in glycitein excretion across studies coupled with the paucity of human data on this isoflavone deserve further investigation.
Starting Page	273
Ending Page	278
Page Count	6
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	2
Issue Number	5
Journal	Food & Function
DOI	10.1039/c1fo10003c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Isoflavones High-performance liquid chromatography Anaerobic organism Daidzein Genistein Glycitein
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Collected literature on isoflavones and chronic diseases

Human nutrition and metabolism urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity1,2.

Human Nutrition and Metabolism Urinary Disposition of the Soybean Isoflavones Daidzein , Genistein and Glycitein Differs among Humans with Moderate Fecal Isoflavone Degradation Activity 1 , 2

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Lesser in vitro anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters

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Collected literature on isoflavones and chronic diseases

Human nutrition and metabolism urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity1,2.

Human Nutrition and Metabolism Urinary Disposition of the Soybean Isoflavones Daidzein , Genistein and Glycitein Differs among Humans with Moderate Fecal Isoflavone Degradation Activity 1 , 2

A New Simplified and Stability Indicating Liquid Chromatography Method for Routine Analysis of Isoflavones Aglycones in Different Complex Matrices

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Lesser in vitro anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters