NDLI: Microbial Metabolism of the Soy Isoflavones Daidzein and Genistein in Postmenopausal Women: Human Intervention Study Reveals New Metabotypes.

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Microbial Metabolism of the Soy Isoflavones Daidzein and Genistein in Postmenopausal Women: Human Intervention Study Reveals New Metabotypes.

Content Provider	Europe PMC
Author	Soukup, Sebastian T. Engelbert, Ann Katrin Watzl, Bernhard Bub, Achim Kulling, Sabine E.
Editor	Bennetau-Pelissero, Catherine Canivenc-Lavier, Marie-Chantal
Copyright Year	2023
Abstract	Background: Soy isoflavones belong to the group of phytoestrogens and are associated with beneficial health effects but are also discussed to have adverse effects. Isoflavones are intensively metabolized by the gut microbiota leading to metabolites with altered estrogenic potency. The population is classified into different isoflavone metabotypes based on individual metabolite profiles. So far, this classification was based on the capacity to metabolize daidzein and did not reflect genistein metabolism. We investigated the microbial metabolite profile of isoflavones considering daidzein and genistein. Methods: Isoflavones and metabolites were quantified in the urine of postmenopausal women receiving a soy isoflavone extract for 12 weeks. Based on these data, women were clustered in different isoflavone metabotypes. Further, the estrogenic potency of these metabotypes was estimated. Results: Based on the excreted urinary amounts of isoflavones and metabolites, the metabolite profiles could be calculated, resulting in 5 metabotypes applying a hierarchical cluster analysis. The metabotypes differed in part strongly regarding their metabolite profile and their estimated estrogenic potency.
Journal	Nutrients
Volume Number	15
PubMed Central reference number	PMC10223177
Issue Number	10
PubMed reference number	37242235
e-ISSN	20726643
DOI	10.3390/nu15102352
Language	English
Publisher	MDPI
Publisher Date	2023-05-17
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	isoflavone daidzein genistein human metabolism metabotypes
Content Type	Text
Resource Type	Article
Subject	Food Science Nutrition and Dietetics

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