NDLI: Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice

Please wait, while we are loading the content...

Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells

Inhibitory effects of Momordica grosvenori Swingle extracts on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mouse skin

Enzyme-modified Panax ginseng inhibits UVB-induced skin aging through the regulation of procollagen type I and MMP-1 expression

A fucose containing polymer-rich fraction from the brown alga Ascophyllum nodosum mediates lifespan increase and thermal-tolerance in Caenorhabditis elegans, by differential effects on gene and protein expression

Photoprotection of human dermal fibroblasts against ultraviolet light by antioxidant combinations present in tomato

Efficient scavenging of β-carotene radical cations by antiinflammatory salicylates

A novel macromolecular extract screened from satsuma with pro-inflammatory effect

The antioxidant activity of soursop decreases the expression of a member of the NADPH oxidase family

The anti-inflammatory effect of a pomegranate husk extract on inflamed adipocytes and macrophages cultivated independently, but not on the inflammatory vicious cycle between adipocytes and macrophages

Enzyme-assisted extraction of κ/ι-hybrid carrageenan from Mastocarpus stellatus for obtaining bioactive ingredients and their application for edible active film development

The functional evaluation of waste yuzu (Citrus junos) seeds

Regulation effect of polysaccharides from Pleurotus tuber-regium (Fr.) on the immune activity of mice macrophages

Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose

Stability of creatine derivatives during simulated digestion in an in vitro model

Realistic intake of a flavanol-rich soluble cocoa product increases HDL-cholesterol without inducing anthropometric changes in healthy and moderately hypercholesterolemic subjects

Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial

Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action

Effects of heme iron enriched peptide on iron deficiency anemia in rats

Back cover

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Kamiyama, Ogusa Ikeda-Obatake, Kyoko Kato, Atsushi Higashi, Yasuhiko Asano, Naoki Adachi, Isao Sanae, Fujiko
Copyright Year	2014
Abstract	We found that the 50% aqueous EtOH extract of clove (Syzygium aromaticum) had potent dose-dependent inhibitory activity toward glycogen phosphorylase b and glucagon-stimulated glucose production in primary rat hepatocytes. Among the components, eugeniin inhibited glycogen phosphorylase b and glucagon-stimulated glucose production in primary rat hepatocytes, with IC50 values of 0.14 and 4.7 μM, respectively. In sharp contrast, eugenol showed no significant inhibition toward glycogen phosphorylase b, even at a concentration of 400 μM. Eugenol-reduced clove extracts (erCE) were prepared and when fed to a db/db mouse they clearly suppressed the blood glucose and HbA1c levels. Furthermore, plasma triglyceride and non-esterified fatty acid levels in 5% and 10% erCE-fed db/db mice were significantly lowered, compared with control db/db mice without erCE supplementation. These results suggested that dietary supplementation with the erCE could beneficially modify glucose and lipid metabolism and contribute to the prevention of the progress of hyperglycemia and metabolic syndrome.
Starting Page	214
Ending Page	219
Page Count	6
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	2
Journal	Food & Function
DOI	10.1039/c3fo60514k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Clove Syzygium Glycogen phosphorylase Glucose Hepatocyte Tellimagrandin II IC50 Eugenol Mouse Glycated hemoglobin Blood plasma Triglyceride Fatty acid Lipid Metabolism Hyperglycemia Syndrome
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus.

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus.

Effects of a high-monounsaturated fat diet on glucose and lipid metabolisms in normal and diabetic mice.

Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes

Hypoglycemic and antioxidant potential of coconut water in experimental diabetes

Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal

Safety and anti-ulcerogenic activity of a novel polyphenol-rich extract of clove buds (Syzygium aromaticum L)

The diagnostic value of glycated albumin in gestational diabetes mellitus

Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice

Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice

Similar Documents

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus.

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus.

Effects of a high-monounsaturated fat diet on glucose and lipid metabolisms in normal and diabetic mice.

Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes

Hypoglycemic and antioxidant potential of coconut water in experimental diabetes

Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal

Safety and anti-ulcerogenic activity of a novel polyphenol-rich extract of clove buds (Syzygium aromaticum L)

The diagnostic value of glycated albumin in gestational diabetes mellitus

Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice

Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice