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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Mukherjee, Subhendu Das, Dipak Kumar Vasanthi, Hannah Rachel Lekli, Istvan Ray, Diptarka Jayachandran, Karuppiah Shanmugasundara Pandian |
| Copyright Year | 2010 |
| Abstract | Hydroalcoholic extract of Dioscorea bulbifera (DB), a yam variety called air potato, was tested for its protective effect on myocardial ischemic/reperfusion (I/R) injury in rats due to apoptosis and necrosis. Myocardial I/R injury was induced by 30 min ischemia followed by 2 h reperfusion by perfusing isolated rat hearts with Krebs Henseilet bicarbonate (KHB) buffer in a Langendorff set up. Pretreatment of DB (150 mg kg−1 body weight) for 30 days significantly reduced myocardial infarct size and improved the ventricular function (aortic flow and coronary flow, LVDP, LVmax dp/dt). Role of DB on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins Bax and Bcl2 by Western blot analysis followed by TUNEL assay. DB also prevented I/R-mediated down regulation of survival protein Akt and HO-1. Our results indicated that Dioscorea bulbifera could ameliorate myocardial ischemia and reperfusion injury by improving ventricular function and inhibition of cardiomyocyte necrosis and apoptosis. |
| Starting Page | 278 |
| Ending Page | 283 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 1 |
| Issue Number | 3 |
| Journal | Food & Function |
| DOI | 10.1039/c0fo00048e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Krebs Henseilet Bax Dioscorea Langendorff Dioscorea bulbifera Cardiac muscle Ischemia Apoptosis Necrosis Bicarbonate Myocardial infarction Aorta Caspase Bcl-2-associated X protein Western blot TUNEL assay Protein Protein kinase B HMOX1 Coronary artery disease Reperfusion injury Cardiac muscle cell |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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