NDLI: Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture

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Contents list

First International Congress on Cocoa Coffee and Tea 2011

Coffee melanoidins: structures, mechanisms of formation and potential health impacts

Coffee, colon function and colorectal cancer

Impact of crema on the aroma release and the in-mouth sensory perception of espresso coffee

Caffeine in hot drinks elicits cephalic phase responses involving cardiac activity

Highly heated food rich in Maillard reaction products limit an experimental colitis in mice

Activation of antioxidant response element (ARE)-dependent genes by roasted coffee extracts

Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture

Characterization of the polymerization of furfuryl alcohol during roasting of coffee

In depth study of acrylamide formation in coffee during roasting: role of sucrose decomposition and lipid oxidation

Understanding the fate of chlorogenic acids in coffee roasting using mass spectrometry based targeted and non-targeted analytical strategies

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Food & Function Vol - 3 Issue - 8

Food & Function Vol - 3 Issue - 7

Food & Function Vol - 3 Issue - 6

Food & Function Vol - 3 Issue - 5

Food & Function Vol - 3 Issue - 4

Food & Function Vol - 3 Issue - 3

Food & Function Vol - 3 Issue - 2

Food & Function Vol -2

Food & Function Vol -1

Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture

Content Provider	Royal Society of Chemistry (RSC)
Author	Rohm, Barbara Riedel, Annett Hochkogler, Christina M. Pignitter, Marc Walker, Jessica Somoza, Veronika Bytof, Gerhard Lantz, Ingo
Copyright Year	2012
Abstract	Caffeine has been hypothesised as a thermogenic agent that might help to maintain a healthy body weight. Since very little is known about its actions on cellular energy metabolism, we investigated the effect of caffeine on mitochondrial oxidative phosphorylation, cellular energy supply and thermogenesis in HepG2 cells, and studied its action on fatty acid uptake and lipid accumulation in 3T3-L1 adipocytes at concentrations ranging from 30–1500 μM. In HepG2 cells, caffeine induced a depolarisation of the inner mitochondrial membrane, a feature of mitochondrial thermogenesis, both directly and after 24 h incubation. Increased concentrations of uncoupling protein-2 (UCP-2) also indicated a thermogenic activity of caffeine. Energy generating pathways, such as mitochondrial respiration, fatty acid oxidation and anaerobic lactate production, were attenuated by caffeine treatment. Nevertheless, HepG2 cells demonstrated a higher energy charge potential after exposure to caffeine that might result from energy restoration through attenuation of energy consuming pathways, as typically found in hibernating animals. In 3T3-L1 cells, in contrast, caffeine increased fatty acid uptake, but did not affect lipid accumulation. We provide evidence that caffeine stimulates thermogenesis but concomitantly causes energy restoration that may compensate enhanced energy expenditure.
Starting Page	955
Ending Page	964
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	3
Issue Number	9
Journal	Food & Function
DOI	10.1039/c2fo30053b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Caffeine Metabolism Oxidative phosphorylation Thermogenesis Fatty acid Lipid Mitochondrion Protein Cellular respiration Anaerobic respiration Lactic acid
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Red blood cell metabolism under prolonged anaerobic storage

N-Methylpyridinium, a degradation product of trigonelline upon coffee roasting, stimulates respiratory activity and promotes glucose utilization in HepG2 cells

Tebuconazole Fungicide Induces Lipid Accumulation and Oxidative Stress in HepG2 Cells

Turn up the cellular power generator with vitamin E analogue formulation

Lipid balance in hepg2 cells: active synthesis and impaired mobilization.

Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells.

Cellular energy metabolism during fetal development ii. Fatty acid oxidation by the developing heart.

A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.

Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture

Similar Documents

Red blood cell metabolism under prolonged anaerobic storage

N-Methylpyridinium, a degradation product of trigonelline upon coffee roasting, stimulates respiratory activity and promotes glucose utilization in HepG2 cells

Tebuconazole Fungicide Induces Lipid Accumulation and Oxidative Stress in HepG2 Cells

Turn up the cellular power generator with vitamin E analogue formulation

Lipid balance in hepg2 cells: active synthesis and impaired mobilization.

Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells.

Cellular energy metabolism during fetal development ii. Fatty acid oxidation by the developing heart.

A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.

Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture