NDLI: <i>Hypericum androsaemum</i> water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway

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Vitamin D insufficiency and chronic diseases: Hype and reality

The health benefits of blackcurrants

Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)

Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells

Protective role of Brassica olerecea and Eugenia jambolana extracts against H₂O₂ induced cytotoxicity in H9C2 cells

Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway

The soluble dietary fiber inulin can influence the bioaccessibility of enniatins

Complexation of high methoxyl pectin with ethanol desolvated whey protein nanoparticles: physico-chemical properties and encapsulation behaviour

Hypotensive, hypoglycaemic and antioxidant effects of consuming a cocoa product in moderately hypercholesterolemic humans

Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine

Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells

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Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway

Content Provider	Royal Society of Chemistry (RSC)
Author	Pereira-Wilson, Cristina Lima, Cristovao F. Xavier, Cristina P. R. Fernandes-Ferreira, Manuel
Copyright Year	2012
Abstract	MAP kinase and PI3K/Akt signalling pathways are commonly altered in colorectal carcinoma (CRC) leading to tumor growth due to increased cell proliferation and inhibition of apoptosis. Several species of the genus Hypericum are used in Portugal to prepare herbal teas to which digestive tract effects are attributed. In the present study, the antiproliferative and proapoptotic effects of the water extracts of H. androsaemum (HA) and H. perforatum (HP) were investigated in two human colon carcinoma-derived cell lines, HCT15 and CO115, which harbour activating mutations of KRAS and BRAF, respectively. Contrarily to HP, HA significantly inhibited cell proliferation and induced apoptosis in both cell lines. HA decreased BRAF and phospho-ERK expressions in CO115, but not in HCT15. HA also decreased Akt phosphorylation in CO115 and induced p38 and JNK in both cell lines. HA induced cell cycle arrest at S and G2/M phases as well as caspase-dependent apoptosis in both cell lines. Chlorogenic acid (CA), the main phenolic compound present in the HA extract and less represented in the HP water extract, did, however, not show any of those effects when used individually. In conclusion, water extract of HA, but not of HP, controlled CRC proliferation and specifically acted on mutant and not wild-type BRAF. The effect of HA was, however, not due to CA alone.
Starting Page	844
Ending Page	852
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	3
Issue Number	8
Journal	Food & Function
DOI	10.1039/c2fo10226a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CRC KRAS HA Portugal Mitogen-activated protein kinase Phosphoinositide 3-kinase Protein kinase B Breast cancer Apoptosis Genus Hypericum Hewlett-Packard Colorectal cancer Harbor BRAF (gene) Phosphorylation P38 mitogen-activated protein kinases C-Jun N-terminal kinases Cell cycle Acid Mutation
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway

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Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway