NDLI: Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection

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Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection

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Food & Function Vol - 7 Issue - 6

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Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection

Content Provider	Royal Society of Chemistry (RSC)
Author	Balamurugan, Krishnaswamy Kamaladevi, Arumugam
Copyright Year	2016
Abstract	In the present study, the effect of Lactic Acid Bacteria (LAB) was investigated at the molecular level using the model organism Caenorhabditis elegans against Klebsiella pneumoniae. Out of the 13 LAB screened, Lactobacillus casei displayed excellent protective efficacy by prolonging the survival of K. pneumoniae-infected nematodes. Pretreatment with L. casei significantly decreased bacterial colonization and rescued K. pneumoniae-infected C. elegans from various physiological impairments. The concomitant upregulation of key immune genes that regulate the TLR, RACK-1 as well as the p38 MAPK pathway rather than the IIS and ERK pathway suggested that the plausible immunomodulatory mechanism of L. casei could be by triggering the TLR, RACK-1 and p38 MAPK pathway. Furthermore, the hyper-susceptibility of L. casei treated loss-of-function mutants of the tol-1, RACK-1 and p38 MAPK pathway (sek-1 and pmk-1) to K. pneumoniae infection and gene expression analysis suggested that L. casei triggered a TLR mediated RACK-1 dependent p38 MAPK pathway to increase host resistance and protect nematodes against K. pneumoniae infection.
Starting Page	3211
Ending Page	3223
Page Count	13
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	7
Journal	Food & Function
DOI	10.1039/c6fo00510a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TLR ERK Caenorhabditis casei Lactobacillales Model organism Staurogyne elegans Klebsiella pneumoniae Lactobacillus casei P38 mitogen-activated protein kinases Mitogen-activated protein kinase MAPK\/ERK pathway Swedish krona Gene
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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