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Food & Function Vol - 7 Issue - 6

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Food & Function Vol - 7 Issue - 4

Food & Function Vol - 7 Issue - 3

Food & Function Vol - 7 Issue - 2

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Food & Function Vol -1

The antiviral effects of acteoside and the underlying IFN-γ-inducing action

Content Provider	Royal Society of Chemistry (RSC)
Author	He, Zhen-Dan Xu, Chen-Shu Zhang, Jian Hao, Yue Xu, Hong He, Jiang Zeng, Yong Fan, Long Hu, Xiao-Peng Song, Xun Wu, Hai-Qiang Li, Yan Liu, Li-Zhong Liao, Cheng-Hui Wu, Xu-Li Zhang, Hong-Jie
Copyright Year	2016
Abstract	There are many herbal teas that are found in nature that may be effective at treating the symptoms and also shortening the duration of viral infections. When combating viral infections, T lymphocytes are an indispensable part of human acquired immunity. However, studies on the use of natural products in stimulating lymphocyte-mediated interferon-gamma (IFN-γ) production are very limited. In this study, we found that acteoside, a natural phenylpropanoid glycoside from Kuding Tea, enhanced IFN-γ production in mouse lymphocytes in a dose-dependent manner, particularly in the CD4+ and CD8+ subsets of T lymphocytes. To this end, we suggest that the antiviral activity of acteoside was highly correlated to its inducing ability of IFN-γ production. Mechanistically, the activation of T-bet enhanced the promoter of IFN-γ and subsequently resulted in an increased IFN-γ production in T cells. Collectively, we have found a natural product with the capacity to selectively enhance mouse T cell IFN-γ production. Given the role of IFN-γ in the immune system, further studies to clarify the role of acteoside in inducing IFN-γ and prevention of viral infection are needed.
Starting Page	3017
Ending Page	3030
Page Count	14
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	7
Journal	Food & Function
DOI	10.1039/c6fo00335d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	T cell Immune system Interferon gamma Verbascoside Phenylpropanoid Kuding Mouse T helper cell Cytotoxic T cell TBX21 Natural product
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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