NDLI: Effects of the olive oil phenol metabolite 3,4-DHPEA-EDAH<sub>2</sub> on human erythrocyte oxidative damage

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Effects of the olive oil phenol metabolite 3,4-DHPEA-EDAH₂ on human erythrocyte oxidative damage

Content Provider	Royal Society of Chemistry (RSC)
Author	Fernandes, J. Santos-Silva, A. Paiva-Martins, F. Ibba, F. Gonçalves, P. Borges, J. E. Przybylska, D.
Copyright Year	2015
Abstract	Red blood cells (RBCs), as anucleated cells, have poor repair and biosynthetic mechanisms, suffering and accumulating oxidative lesions whenever oxidative stress develops. RBCs are particularly exposed to endogenous oxidative damage because of their specific role as oxygen carriers. However, as the most abundant blood cells, RBCs also play an important role in the oxidative status of the whole blood constituents. In previous studies by our group, the most important polyphenolic compounds found in virgin olive oil, 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) and 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde (3,4-DHPEA-EDA), were shown to significantly protect RBCs from oxidative damage initiated by AAPH and H2O2, with the most active compound being 3,4-DHPEA-EDA. However, the in vivo protective effects of these phenols are dependent on their bioavailability. It has been demonstrated that 3,4-DHPEA-EDA is absorbed by intestinal cells and is then metabolized, yielding a reduced metabolite, 3,4-DHPEA-EDAH2. In order to assess the importance of VOO phenolic compound metabolites for the overall in vivo protective activity, the capacity of this phase I metabolite to protect RBCs in the presence of the radical initiators AAPH or H2O2 was evaluated in the presence and absence of the naturally occurring antioxidant, ascorbic acid. The metabolite was shown to protect RBCs from haemolysis induced by both initiators, in a dose dependent way, after 2 h and 4 h of incubation. The protective effect was however lower than that of the parental compound. The analysis of the membrane proteins of erythrocytes showed that the metabolite can interact with these biological structures.
Starting Page	2350
Ending Page	2356
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	7
Journal	Food & Function
DOI	10.1039/c5fo00203f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Oxygen Olive oil Carboxylic acid Hydrogen peroxide Bioavailability Metabolite Antioxidant Hemolysis Red blood cell Drug interaction
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Effects of the olive oil phenol metabolite 3,4-DHPEA-EDAH2 on human erythrocyte oxidative damage

Effects of the olive oil phenol metabolite 3,4-DHPEA-EDAH₂ on human erythrocyte oxidative damage