NDLI: Organometallic gold(iii) complexes with hybrid <i>SNS</i>-donating thiosemicarbazone ligands: cytotoxicity and anti-<i>Trypanosoma cruzi</i> activity

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Dalton Transactions Vol -46

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Functional metallosupramolecular architectures using 1,2,3-triazole ligands: it's as easy as 1,2,3 “click”

Synthesis and structural study of new metallasilsesquioxanes of potassium and uranium

Transition metal free catalytic hydroboration of aldehydes and aldimines by amidinato silane

Tuning the stability of bimetallic Ce(iv)/Zr(iv)-based MOFs with UiO-66 and MOF-808 structures

Ag-NPs embedded in two novel Zn₃/Zn₅-cluster-based metal–organic frameworks for catalytic reduction of 2/3/4-nitrophenol

Hydrophenoxylation of internal alkynes catalysed with a heterobimetallic Cu-NHC/Au-NHC system

Comparative electronic structures of nitrogenase FeMoco and FeVco

A luminescent metal organic framework with high sensitivity for detecting and removing copper ions from simulated biological fluids

Metal–organic frameworks utilising an interlocked, hexadentate linker containing a tetra-carboxylate axle and a bis(pyridine) wheel

Single-molecule magnet behaviour in a tetranuclear Dy^III complex formed from a novel tetrazine-centered hydrazone Schiff base ligand

A new 3-D open-framework Li-rich vanadoborate and its high ionic conductivity after transforming into glasses

Palladacycles of sulfated and selenated Schiff bases of ferrocene-carboxaldehyde as catalysts for O-arylation and Suzuki–Miyaura coupling

Manganese-containing ionic liquids: synthesis, crystal structures and electrodeposition of manganese films and nanoparticles

Thermoelectric properties of Bi_1−xSn_xCuSeO solid solutions

Polynuclear cage-like Au(i) phosphane complexes based on a S²⁻ template: observation of multiple luminescence in coordinated polyaromatic systems

Intracellular detection of hazardous Cd²⁺ through a fluorescence imaging technique by using a nontoxic coumarin based sensor

Heterodinuclear titanium/zinc catalysis: synthesis, characterization and activity for CO₂/epoxide copolymerization and cyclic ester polymerization

Bonding trends across the series of tricarbonato-actinyl anions [(AnO₂)(CO₃)₃]⁴⁻ (An = U–Cm): the plutonium turn

Sterically directed nitronate complexes of 2,6-di-tert-butyl-4-nitrophenoxide with Cu(ii) and Zn(ii) and their H-atom transfer reactivity

Organometallic gold(iii) complexes with hybrid SNS-donating thiosemicarbazone ligands: cytotoxicity and anti-Trypanosoma cruzi activity

Deactivation of the coordinating ability of the iminophosphorane group by the effect of ortho-carborane

Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion

Sequence of phase transitions in (NH₄)₃SiF₇

One-pot synthesis of ultrastable pentanuclear alkylzinc complexes

Three new energetic complexes with N,N-bis(1H-tetrazole-5-yl)-amine as high energy density materials: syntheses, structures, characterization and effects on the thermal decomposition of RDX

A promising lead-free fluoride carbonate SHG material designed from a theoretical perspective

Band-gap tailoring and visible-light-driven photocatalytic performance of porous (GaN)_1−x(ZnO)_x solid solution

An efficient synthetic method for organometallic radicals: structures and properties of gold(i)-(nitronyl nitroxide)-2-ide complexes

Cu²⁺ recognition by N,N′-benzylated bis(amino amides)

Synthesis and evaluation of new copper ketoiminate precursors for a facile and additive-free solution-based approach to nanoscale copper oxide thin films

Photomagnetic properties of an Fe(ii) spin-crossover complex of 6-(3,5-diamino-2,4,6-triazinyl)-2,2′-bipyridine and its insertion into 2D and 3D bimetallic oxalate-based networks

Redox properties and electron transfer in a triarylamine-substituted HS-Co²⁺/LS-Co³⁺ redox couple

Determination of ZFS parameters from the EPR spectra of mono-, di- and trinuclear Mn^II complexes: impact of magnetic coupling

Tailored synthesis of nonlinear optical quaternary chalcohalides: Ba₄Ge₃S₉Cl₂, Ba₄Si₃Se₉Cl₂ and Ba₄Ge₃Se₉Cl₂

Influence of wing-tip substituents and reaction conditions on the structure, properties and cytotoxicity of Ag(i)– and Au(i)–bis(NHC) complexes

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Organometallic gold(iii) complexes with hybrid SNS-donating thiosemicarbazone ligands: cytotoxicity and anti-Trypanosoma cruzi activity

Content Provider	Royal Society of Chemistry (RSC)
Author	Hagenbach, A. Lopes, C. D. Oliveira, C. G. Albuquerque, S. de Deflon, V. M. Maia, P. I. da S. Silva, J. S. Carneiro, Z. A. Abram, U. Gust, R.
Copyright Year	2017
Abstract	Stable organogold(III) compounds of the composition [AuIII(Hdamp)(L1)]Cl are formed from reactions of [AuCl2(damp)] with H2L1 (damp− = dimethylaminomethylphenyl; H2L1 = N′-(diethylcarbamothioyl)benzimidothiosemicarbazides). The cationic complexes can be neutralized by reactions with weak bases under the formation of [AuIII(damp)(L1)] compounds. The structures of the products show interesting features like relatively short Au⋯H contacts between the methylene protons of the Hdamp ligand and the gold(III) ions. Preliminary biological studies on the uncoordinated compounds H2L1 and their gold complexes indicate considerable cytotoxicity for the [AuIII(Hdamp)(L1)]Cl complexes against MCF-7 cells. The in vitro trypanocidal activity was evaluated against the intracellular form of Trypanosoma cruzi. The organometallic complexes display a remarkable activity, which is dependent on the alkyl substituents of the thiosemicarbazone building blocks of the ligands. One representative of the cationic [AuIII(Hdamp)(L1)]Cl complexes, where H2L1 contains a dimethylthiosemicarbazide building block, shows a trypanocidal activity against the intracellular amastigote form in the same order of magnitude as that of the standard drug benznidazole. Furthermore, no appreciable toxicity to mice spleen cells is observed for this compound resulting in a therapeutic index of about 30, which strongly recommends it as a promising candidate for the development of a future antiparasitic drug.
Starting Page	2559
Ending Page	2571
Page Count	13
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	46
Issue Number	8
Journal	Dalton Transactions
DOI	10.1039/c6dt04307k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Trypanosoma Methylene bridge Ligand Cytotoxicity MCF-7 Organometallic chemistry Alkyl Semicarbazone Amastigote Benznidazole Spleen Antiparasitic
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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Organometallic gold(III) [Au(Hdamp)(L14)]Cl (L1 = SNS-donating thiosemicarbazone) complex protects mice against acute T. cruzi infection

Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity

Nickel II ruthenium II III and rhodium I complexes bearing quinone based thiosemicarbazone semicarbazone ligands synthesis characterization and applications

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Rhenium mixed-ligand complexes with S,N,S-tridentate thiosemicarbazone/ thiosemicarbazide ligands

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Synthesis, characterization and in vitro anticancer activities of semicarbazone and thiosemicarbazone derivatives of salicylaldehyde and their copper complexes against human breast cancer cell line MCF-7

Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands

Iron(III) Complexes of 2,4-Dihydroxybenzophenone Semicarbazone (DBPS) & Thiosemicarbazone (DBPT) & Determination of Iron(III) using DBPS & DBPT

Organometallic gold(iii) complexes with hybrid SNS-donating thiosemicarbazone ligands: cytotoxicity and anti-Trypanosoma cruzi activity

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