NDLI: Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[MI(CO)3]+ (M = Re, 99mTc) complexes

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Dalton Transactions Vol - 46 Issue - 3

Dalton Transactions Vol - 46 Issue - 2

Dalton Transactions Vol -39

Dalton Transactions Vol -0

Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[M^I(CO)₃]⁺ (M = Re, ^99mTc) complexes

Content Provider	Royal Society of Chemistry (RSC)
Author	Hayes, Thomas R. Barnes, Charles L. Bottorff, Shalina C. Benny, Paul D. Slocumb, Winston S. Clark, Aurora E.
Copyright Year	2017
Abstract	In the last two decades, a number of chelate strategies have been proposed for the fac-[MI(CO)3]+ (M = Re, 99mTc) core in radiopharmaceutical applications. However, the development of new ligands/complexes with improved function and in vivo performance has been limited in recent years. Expanding on our previous studies using the 2 + 1 labeling strategy, a series of bidentate ligands (neutral vs. anionic) containing an aromatic amine in combination with monodentate pyridine analogs or imidazole were explored to determine the influence of the bidentate and monodentate ligands on the formation and stability of the respective complexes. The 2 + 1 complexes with Re and 99mTc were synthesized in two steps and characterized by standard radio/chemical methods. X-ray characterization and density functional theory analysis of the Re 2 + 1 complexes with the complete bidentate series with 4-dimethylaminopyridine were conducted, indicating enhanced ligand binding energies of the neutral over anionic ligands. In the 99mTc studies, anionic bidentate ligands had significantly higher formation yields of the 2 + 1 product, but neutral ligands appear to have increased stability in an amino acid challenge assay. Both bidentate series exhibited improved stability by increasing the basicity of the pyridine ligands.
Starting Page	1134
Ending Page	1144
Page Count	11
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	46
Issue Number	4
Journal	Dalton Transactions
DOI	10.1039/c6dt04282a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Technetium-99m Medicinal radiocompounds Denticity Aromatic amine Pyridine Imidazole X-ray crystallography Density functional theory 4-Dimethylaminopyridine Ligand Carboxylic acid
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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Several Novel N-Donor Tridentate Ligands Formed in Chemical Studies of New fac-Re(CO)3 Complexes Relevant to fac-99mTc(CO)3 Radiopharmaceuticals: Attack of a Terminal Amine on Coordinated Acetonitrile

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