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Dalton Transactions Vol -39

Dalton Transactions Vol -0

Theranostic TEMPO-functionalized Ru(ii) complexes as photosensitizers and oxidative stress indicators

Content Provider	Royal Society of Chemistry (RSC)
Author	Hu, Wei-Liang Ji, Liang-Nian Cao, Qian Mao, Zong-Wan Yang, Jing Ye, Rui-Rong He, Liang Qin, Peter Z.
Copyright Year	2017
Abstract	New TEMPO-functionalized Ru(II) polypyridyl complexes were synthesized as efficient theranostic photosensitizers for cancer treatment. Interestingly, due to the presence of a redox sensitive TEMPO moiety, an enhancement in the intracellular fluorescence of TEMPO-functionalized Ru(II) complexes was observed during photodynamic treatment in both confocal microscopy and flow cytometry. This can be explained by the conversion of the TEMPO radical moiety to diamagnetic non-radical species in cells upon PDT-induced oxidative stress. To the best of our knowledge this is the first ruthenium complex capable of simultaneously inducing and monitoring the oxidative stress. The tethered TEMPO moiety decreased the inherent dark-cytotoxicity and increased the photo-toxicity simultaneously, both of which contributed to the greatly improved photodynamic therapy (PDT) efficacy, ultimately resulting in cancer cell apoptosis. The phototoxicity index value for TEMPO-functionalized Ru(II) complexes was selective towards cancer cell lines (280.5 for HeLa cells vs. 30.2 for LO2 cells) and ca. 40-fold higher than that for TEMPO-free Ru(II) analogues (6.7 for HeLa cells). The main contributor for such a greatly enhanced PDT efficacy was the effect of the TEMPO moiety on the cellular uptake and intracellular ROS levels. We therefore demonstrate that the combination of TEMPO with the photosensitizers may be an emerging strategy to develop novel photosensitizer-based theranostic platforms, which can induce and monitor the PDT response simultaneously.
Starting Page	445
Ending Page	454
Page Count	10
File Format	HTM / HTML PDF
ISSN	14779226
Volume Number	46
Issue Number	2
Journal	Dalton Transactions
DOI	10.1039/c6dt04028d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cancer Redox Fluorescence Confocal microscopy Flow cytometry Diamagnetism Oxidative stress Ruthenium Photodynamic therapy Apoptosis Phototoxicity HeLa Liquid oxygen Reactive oxygen species
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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