NDLI: Constructing NIR silica–cyanine hybrid nanocomposite for bioimaging <i>in vivo</i>: a breakthrough in photo-stability and bright fluorescence with large Stokes shift

Content Provider	Royal Society of Chemistry (RSC)
Author	Shi, Jianlin Chang, Shu Wu, Xumeng Zhu, Weihong Sun, Xuanrong Tian, He Guo, Zhiqian Li, Yongsheng Shen, Youqing Tang, Jianbin
Copyright Year	2013
Abstract	Optical near-infrared (NIR) nanomaterials provide a unique opportunity for applications in bioimaging and medical diagnosis. A kind of hydrophilic NIR fluorescent core–shell structured silica nanoparticle containing NIR cyanine chromophore, named as CyN-12@NHs, for in vivo bioimaging is developed through a facile one-pot strategy. The hydrophobic CyN-12 molecules can be successfully encapsulated into the core via the self-assembly of the amphiphilic block copolymer PS-b-PAA and subsequent shell cross-linking of silane. The as-prepared CyN-12@NHs exhibits typically spherical core–shell structure, which has a uniform size of 35 nm with a narrow size distribution, and excellent dispersity in aqueous solution. Moreover, NIR absorption (690 nm) and bright fluorescence (800 nm) of CyN-12@NHs with a large Stokes shift (110 nm) in aqueous system make it an amenable high quality bioimaging contrast agent. The core–shell nanostructure significantly enhances the chemical and photo-stability of CyN-12 via the encapsulation, which possesses a 50-times longer half-life period than free CyN-12, along with a better resistance to reactive oxygen species (ROS). Furthermore, in living cell imaging, CyN-12@NHs shows nearly no cytotoxicity and is able to outline the HepG2 cells. The in vivo imaging on a tumor-bearing mouse model indicates that CyN-12@NHs selectively accumulates in the liver after intravenous injection, and has a long retention in tumor after intra-tumor injection without decrease in fluorescence activity. Overall, the excellent photo-properties of CyN-12@NHs could meet the intricate requirements for tumor imaging, such as high sensitivity, sufficient tissue penetration, and high spatial resolution. The strategy of the silica–cyanine hybrid nanoparticles paves a desirable and efficient route to fabricate highly hydrophilic NIR fluorescent contrast agents for tumor imaging and therapy, especially with a breakthrough in photo-stability, bright fluorescence as well as large Stokes shift.
Starting Page	1221
Ending Page	1228
Page Count	8
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	4
Issue Number	3
Journal	Chemical Science
DOI	10.1039/c2sc22035k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Stokes shift Reactive oxygen species Nanoparticle Liver Fluorescence Nanomaterials Contrast medium Cytotoxicity Nanostructure Hydrophobe Silicon dioxide Self-assembly Stokes NIR Amphiphile Hydrophile Cyanine Copolymer Half-life Silane Chromophore
Content Type	Text
Resource Type	Article
Subject	Chemistry

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