NDLI: Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators

Content Provider	Royal Society of Chemistry (RSC)
Author	Capicciotti, Chantelle J. Perras, Frédéric A. Bryce, David L. Paulin, Hilary Ben, Robert N. Harden, James Liu, Yun Leclère, Mathieu
Copyright Year	2012
Abstract	Ice recrystallization inhibition (IRI) activity is a very desirable property for an effective cryoprotectant. This property was first observed in biological antifreezes (BAs), which cannot be utilized in cryopreservation due to their ability to bind to ice. To date, potent IRI active compounds have been limited to BAs or synthetic C-linked AFGP analogues (1 and 2), all of which are large peptide-based molecules. This paper describes the first example of low molecular weight carbohydrate-based derivatives that exhibit potent IRI activity. Non-ionic surfactant n-octyl-β-D-galactopyranoside (4) exhibited potent IRI activity at a concentration of 22 mM, whereas hydrogelator N-octyl-D-gluconamide (5) exhibited potent IRI activity at a low concentration of 0.5 mM. Thermal hysteresis measurements and solid-state NMR experiments indicated that these derivatives are not exhibiting IRI activity by binding to ice. For non-ionic surfactant derivatives (3 and 4), we demonstrated that carbohydrate hydration is important for IRI activity and that the formation of micelles in solution is not a prerequisite for IRI activity. Furthermore, using solid-state NMR and rheology we demonstrated that the ability of hydrogelators 5 and 6 to form a hydrogel is not relevant to IRI activity. Structure–function studies indicated that the amide bond in 5 is an essential structural feature required for potent IRI activity.
Starting Page	1408
Ending Page	1416
Page Count	9
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	3
Issue Number	5
Journal	Chemical Science
DOI	10.1039/c2sc00885h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	IRI Cryoprotectant Cryopreservation Solid-state nuclear magnetic resonance Rheology Crystallization Covalent bond Amide Carbohydrate Surfactant Hysteresis Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators

Recrystallization inhibition in ice due to ice binding protein activity detected by nuclear magnetic resonance

Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant

The gelatin-based liquid marbles for cell cryopreservation.

Amidoamine Oxide Surfactants as Low-Molecular-Weight Hydrogelators: Effect of Methylene Chain Length on Aggregate Structure and Rheological Behavior.

Effect of Marine-Derived Ice-Binding Proteins on the Cryopreservation of Marine Microalgae

Tricine as a Novel Cryoprotectant with Osmotic Regulation, Ice Recrystallization Inhibition and Antioxidant Properties for Cryopreservation of Red Blood Cells

Atomic refinement using orientational restraints from solid-state NMR.

Boron–boron J coupling constants are unique probes of electronic structure: a solid-state NMR and molecular orbital study

Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators

Similar Documents

Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators

Recrystallization inhibition in ice due to ice binding protein activity detected by nuclear magnetic resonance

Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant

The gelatin-based liquid marbles for cell cryopreservation.

Amidoamine Oxide Surfactants as Low-Molecular-Weight Hydrogelators: Effect of Methylene Chain Length on Aggregate Structure and Rheological Behavior.

Effect of Marine-Derived Ice-Binding Proteins on the Cryopreservation of Marine Microalgae

Tricine as a Novel Cryoprotectant with Osmotic Regulation, Ice Recrystallization Inhibition and Antioxidant Properties for Cryopreservation of Red Blood Cells

Atomic refinement using orientational restraints from solid-state NMR.

Boron–boron J coupling constants are unique probes of electronic structure: a solid-state NMR and molecular orbital study

Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators