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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Zhang, Yejun Ding, Mingmin Qu, Chunrong Ding, Bingbing Zhou, Hui Er-bu, AGA Sun, Yao Zeng, Xiaodong Wu, Huaping Hou, Wei Cheng, Zhen Xiao, Yuling Hong, Xuechuan |
| Copyright Year | 2017 |
| Abstract | Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY ≈ 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and image-guided surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II image-guided sentinel lymph node (SLN) surgery. |
| Starting Page | 3489 |
| Ending Page | 3493 |
| Page Count | 5 |
| File Format | HTM / HTML PDF |
| ISSN | 20416520 |
| Volume Number | 8 |
| Issue Number | 5 |
| Journal | Chemical Science |
| DOI | 10.1039/c7sc00251c |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Subscribed |
| Subject Keyword | Fluorene Succinate dehydrogenase SLN Lymph node Sentinel lymph node Fluorescence Biocompatibility Image-guided surgery Chromatography Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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