NDLI: SABRE hyperpolarisation of vitamin B3 as a function of pH

Content Provider	Royal Society of Chemistry (RSC)
Author	Green, G. G. R. Olaru, A. M. Duckett, S. B. Burns, M. J.
Copyright Year	2017
Abstract	In this work we describe how the signal enhancements obtained through the SABRE process in methanol-d4 solution are significantly affected by pH. Nicotinic acid (vitamin B3, NA) is used as the agent, and changing pH is shown to modify the level of polarisation transfer by over an order of magnitude, with significant improvements being seen in terms of the signal amplitude and relaxation rate at high pH values. These observations reveal that manipulating pH to improve SABRE enhancements levels may improve the potential of this method to quantify low concentrations of analytes in mixtures. 1H NMR spectroscopy results link this change to the form of the SABRE catalyst, which changes with pH, resulting in dramatic changes in the magnitude of the ligand exchange rates. The presented data also uses the fact that the chemical shifts of the nicotinic acids NMR resonances are affected by pH to establish that hyperpolarised 1H-based pH mapping with SABRE is possible. Moreover, the strong polarisation transfer field dependence shown in the amplitudes of the associated higher order longitudinal terms offers significant opportunities for the rapid detection of hyperpolarised NA in H2O itself without solvent suppression. 1H and 13C MRI images of hyperpolarised vitamin B3 in a series of test phantoms are presented that show pH dependent intensity and contrast. This study therefore establishes that when the pH sensitivity of NA is combined with the increase in signal gain provided for by SABRE hyperpolarisation, a versatile pH probe results.
Starting Page	2257
Ending Page	2266
Page Count	10
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	8
Issue Number	3
Journal	Chemical Science
DOI	10.1039/c6sc04043h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Hyperpolarization (biology) Acid Properties of water Pyridinecarboxylic acids Ligand Nuclear magnetic resonance spectroscopy Niacin Roadgeek Magnetic resonance imaging SABRE PH Nuclear magnetic resonance Correlation and dependence Solvent
Content Type	Text
Resource Type	Article
Subject	Chemistry

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