NDLI: Encapsulation of Pt(iv) prodrugs within a Pt(ii) cage for drug delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Suntharalingam, Kogularamanan Lippard, Stephen J. Zheng, Yao-Rong Johnstone, Timothy C.
Copyright Year	2015
Abstract	This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that can host four Pt(IV) prodrug guest molecules. Relying on host–guest interactions between adamantyl units tethered to the Pt(IV) molecules and the cage, four prodrugs could be encapsulated within one cage. This host–guest complex, exhibiting a diameter of about 3 nm, has been characterized by detailed NMR spectroscopic measurements. Owing to the high positive charge, this nanostructure exhibits high cellular uptake. Upon entering cells and reacting with biological reductants such as ascorbic acid, the host–guest complex releases cisplatin, which leads to cell cycle arrest and apoptosis. The fully assembled complex displays cytotoxicity comparable to that of cisplatin against a panel of human cancer cell lines, whereas the cage or the Pt(IV) guest alone exhibit lower cytotoxicity. These findings indicate the potential of utilising well-defined supramolecular constructs for the delivery of prodrug molecules.
Starting Page	1189
Ending Page	1193
Page Count	5
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	6
Issue Number	2
Journal	Chemical Science
DOI	10.1039/c4sc01892c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Acid Adamantane Cell cycle Cytotoxicity Nanostructure Prodrug Nuclear magnetic resonance Cisplatin Apoptosis Cancer
Content Type	Text
Resource Type	Article
Subject	Chemistry

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Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery

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