NDLI: Bioinspired polydopamine nanospheres: a superquencher for fluorescence sensing of biomolecules

Content Provider	Royal Society of Chemistry (RSC)
Author	Xu, Danke Qiang, Weibing Li, Xiaoqing Li, Wei Chen, Xiang
Copyright Year	2014
Abstract	The strong fluorescence quenching ability towards a wide spectrum of fluorescent dyes of bioinspired polydopamine nanospheres was shown for the first time. Up to 97% quenching efficiency via energy transfer and/or electron transfer was obtained towards four kinds of fluorophores, aminomethylcoumarin acetate (AMCA), 6-carboxyfluorescein (FAM), 6-carboxytetramethylrhodamine (TAMRA) and Cy5. This fluorescence quenching ability compared favorably with that of graphene oxide, the superquencher. The nanospheres (NS) also exhibit different affinities for various ssDNA conformations. Furthermore, FAM-labeled ssDNA was adsorbed onto NS through non-covalent binding to form an ssDNA/NS complex, leading to the quenching of the fluorescence of FAM. This complex was used as a sensing platform for the detection of DNA and proteins based on the fluorescence recovery due to target recognition. The LODs of DNA and thrombin were equal or close to those of GO-based biosensors. The assay is fast, simple and homogeneous, and could be used for fluorescence imaging. The excellent biocompatibility and biodegradability of polydopamine also render it suitable for in vivo applications.
Starting Page	3018
Ending Page	3024
Page Count	7
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	5
Issue Number	8
Journal	Chemical Science
DOI	10.1039/c4sc00085d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Football Association of Malaysia Graphene DNA Fluorescence Thrombin Biocompatibility
Content Type	Text
Resource Type	Article
Subject	Chemistry

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