NDLI: A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Please wait, while we are loading the content...

Chlorination as a useful method to modulate conjugated polymers: balanced and ambient-stable ambipolar high-performance field-effect transistors and inverters based on chlorinated isoindigo polymers

Induced self-assembly and disassembly of water-soluble alkynylplatinum(ii) terpyridyl complexes with “switchable” near-infrared (NIR) emission modulated by metal–metal interactions over physiological pH: demonstration of pH-responsive NIR luminescent probes in cell-imaging studies

Spin crossover or intra-molecular electron transfer in a cyanido-bridged Fe/Co dinuclear dumbbell: a matter of state

Electrical conductance study on 1,3-butadiyne-linked dinuclear ruthenium(ii) complexes within single molecule break junctions

Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Stabilizing unstable species through single-site isolation: a catalytically active Ta^V trialkyl in a porous organic polymer

Emission wavelength variation with changes in excitation in a Re(i)–bisthiazole ligand complex that breaks the Kasha–Vavilov rule

Highly efficient one-pot ligation and desulfurization

Unraveling the peculiar modus operandi of a new class of solvatochromic fluorescent molecular rotors by spectroscopic and quantum mechanical methods

C–H⋯π interactions as modulators of carbocation structure – implications for terpene biosynthesis

On the evaporation, bonding, and adsorbate capture of an ionic liquid on Au(111)

Top-contacting molecular monolayers using single crystalline Au microplate electrodes

Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H₂O₂-responsive controlled drug release for potential Alzheimer's disease treatment

Understanding the competitive dehydroalkoxylation and dehydrogenation of ethers with Ti–C multiple bonds

A near-infrared ratiometric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells

Squaraine rotaxane shuttle as a ratiometric deep-red optical chloride sensor

Characterization of silver ion dissolution from silver nanoparticles using fluorous-phase ion-selective electrodes and assessment of resultant toxicity to Shewanella oneidensis

One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method

Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution

Iridium(iii)-bis(oxazolinyl)phenyl catalysts for enantioselective C–H functionalization

The transition from liquid to solid-like behaviour in ultrahigh viscosity aerosol particles

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity

Access to congested quaternary centers by Pd-catalyzed intermolecular γ-arylation of unactivated α,β-unsaturated aldehydes

Synthesis of cyclobutane lignans via an organic single electron oxidant–electron relay system

Light-emitting platinum(ii) complexes supported by tetradentate dianionic bis(N-heterocyclic carbene) ligands: towards robust blue electrophosphors

Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

Enantioselective intermolecular bromoesterification of allylic sulfonamides

Remarkable coordination behavior of alkyl isocyanides toward unsaturated vicinal frustrated P/B Lewis pairs

Rh(iii)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols

Synthesis of nitrodienes, nitrostyrenes, and nitrobiaryls through palladium-catalyzed couplings of β-nitrovinyl and o-nitroaryl thioethers

Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C–H bond activation

Well-defined silica-supported molybdenum nitride species: silica grafting triggers alkyne metathesis activity

Carbocyclization of unsaturated thioesters under palladium catalysis

Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp²)–H bonds and aryl C(sp²)–H bonds using TBHP

Back cover

Chemical Science Vol - 4 Issue - 5

Chemical Science Vol - 4 Issue - 4

Chemical Science Vol - 4 Issue - 3

Chemical Science Vol - 4 Issue - 2

Chemical Science Vol -3

Chemical Science Vol -2

Chemical Science Vol -1

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Qiu, Lin Wang, Jinzhuan Zhang, Changli Guo, Zijian Wu, Mingmin Song, Yajie Chang, Cunjie Yan, Jun Wang, Jing Wang, Xiaoyong
Copyright Year	2013
Abstract	Superparamagnetic iron oxide nanoparticles (SPION) are potential drug carriers and a magnetic resonance imaging (MRI) contrast agent for cancer therapy and diagnosis. In this study, dechlorinated cisplatin (CMDP) is tethered to maghemite nanoparticles modified with 4-oxo-4-(3-(triethoxysilyl)propylamino)butanoic acid (OTPBA–SPION) through the surface carboxylate groups. The nanocomposite (CMDP–OTPBA–SPION) was characterized by TEM, XPS, EDX, SQUID, ICP-AES, and zeta potential. A relatively high Pt loading capacity (ca. 13%) is achieved with this drug delivery system. The DNA binding ability of CMDP–OTPBA–SPION is prominent in acidic medium (pH 5.2) but is insignificant under normal physiological conditions (pH 7.4), suggesting that an acidic cancerous environment is favourable for the release of the platinum pharmacophore from the composite. The transverse relaxivity of CMDP–OTPBA–SPION in phosphate-buffered saline is 141.9 mM−1 s−1 in terms of Fe concentration, implying that the composite could be used as a negative-contrast agent for MRI. The cytotoxicity of the composite toward MCF-7 and HeLa cancer cells displays slow and time-dependent characteristics, reaching a level comparable to that of cisplatin at 72 h. The diagnostic capability and tumor-specific accumulation of the composite are verified in vitro and in vivo by the time-dependent negative-contrast enhancement effect in MRI using MCF-7 cells and tumor-bearing mice, respectively. The results demonstrate that CMDP–OTPBA–SPION can potentially be used as an anticancer theranostic agent for simultaneous targeted therapy and MRI under an external magnetic field.
Starting Page	2605
Ending Page	2612
Page Count	8
File Format	HTM / HTML PDF
ISSN	20416520
Volume Number	4
Issue Number	6
Journal	Chemical Science
DOI	10.1039/c3sc50554e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Acid Iron oxide SQUID Targeted therapy MCF-7 CMDP Contrast medium Inductively coupled plasma atomic emission spectroscopy Cytotoxicity Drug delivery Cisplatin HeLa Transmission electron microscopy Magnetic resonance imaging Zeta potential DNA PH Nanocomposite Pharmacophore Magnetic field Maghemite Cancer
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles

The Cytotoxicity of Dextran-coated Iron Oxide Nanoparticles on Hela and MCF-7 Cancerous Cell Lines

Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

The Cytotoxicity of Dextran-coated Iron Oxide Nanoparticles on Hela and MCF-7 Cancerous Cell Lines

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

Glioma-targeted superparamagnetic iron oxide nanoparticles as drug-carrying vehicles for theranostic effects

Effects of cisplatin conjugate nanoparticles on breast cancer in vitro and in vivo.

Synthesis and Cytotoxicity Assessment of Gold-coated Magnetic Iron Oxide Nanoparticles

Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Similar Documents

4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles

The Cytotoxicity of Dextran-coated Iron Oxide Nanoparticles on Hela and MCF-7 Cancerous Cell Lines

Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

The Cytotoxicity of Dextran-coated Iron Oxide Nanoparticles on Hela and MCF-7 Cancerous Cell Lines

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

Glioma-targeted superparamagnetic iron oxide nanoparticles as drug-carrying vehicles for theranostic effects

Effects of cisplatin conjugate nanoparticles on breast cancer in vitro and in vivo.

Synthesis and Cytotoxicity Assessment of Gold-coated Magnetic Iron Oxide Nanoparticles

Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles