NDLI: “Leaching or not leaching”: an alternative approach to antimicrobial materials <i>via</i> copolymers containing crown ethers as active groups

Please wait, while we are loading the content...

Magnetic nanoparticles for drug targeting: from design to insights into systemic toxicity. Preclinical evaluation of hematological, vascular and neurobehavioral toxicology

Development of kartogenin-conjugated chitosan–hyaluronic acid hydrogel for nucleus pulposus regeneration

A fluorescent light-up aggregation-induced emission probe for screening gefitinib-sensitive non-small cell lung carcinoma

The correlation between osteopontin adsorption and cell adhesion to mixed self-assembled monolayers of varying charges and wettability

A novel botryoidal aramid fiber reinforcement of a PMMA resin for a restorative biomaterial

Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility

Rapid fabrication of functionalised poly(dimethylsiloxane) microwells for cell aggregate formation

Bioresorbable polypeptide-based comb-polymers efficiently improves the stability and pharmacokinetics of proteins in vivo

PEGylation corannulene enhances response of stress through promoting neurogenesis

Back cover

Biomaterials Science Vol - 5 Issue - 3

Biomaterials Science Vol - 5 Issue - 2

Biomaterials Science Vol - 5 Issue - 1

Biomaterials Science Vol -4

Biomaterials Science Vol -3

Biomaterials Science Vol -2

Biomaterials Science Vol -1

“Leaching or not leaching”: an alternative approach to antimicrobial materials via copolymers containing crown ethers as active groups

Content Provider	Royal Society of Chemistry (RSC)
Author	Gorrasi, G. Capaccio, V. Izzo, L. Adami, R. Reverchon, E. Rosa, M. De Vigliotta, G. Soriente, A. Mella, M.
Copyright Year	2017
Abstract	In this work, new copolymers containing either MMA and 18C6 crown-ether pendants, or PEG, MMA and 18C6 crown-ether pendants were synthesized to test the idea that sequestering structural alkali-earth ions from the bacterial outer membrane (OM) may lead to bacterial death. The copolymers were obtained either via uncontrolled radical polymerization or ATRP; the latter approached allowed us to produce not only linear copolymers but also branched Y-like structures. After checking for the capability of complexing magnesium and calcium ions, the antimicrobial activity of all copolymers was tested placing their casted plaques in contact with pure water E. coli suspensions. All plaques adsorbed alkali-earth ions and killed bacteria, albeit with different antimicrobial efficiencies. Differences in the latter characteristic were attributed to different plaque roughness. The role of the 18C6 crown-ether pendants was elucidated by pre-saturating plaques with Mg/Ca ions, the marked reduction in antimicrobial efficiency indicating that losing the latter from OM due to surface complexation does play an important role in killing bacteria at short (<5 h) contact times. At longer times, the mode of action is instead related to the poly-cationic nature acquired by the plaques due to ion sequestering.
Starting Page	741
Ending Page	751
Page Count	11
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	5
Issue Number	4
Journal	Biomaterials Science
DOI	10.1039/c6bm00950f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MMA Antimicrobial Bacterial outer membrane Calcium Escherichia coli Radical polymerization Bacteria Ion Magnesium OM Bactericide ATRP
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

ATRP of MMA in Aqueous Solution in the Presence of an Amphiphilic Polymeric Macroligand

Facile Synthesis of Well-Defined MDMO-PPV Containing (Tri)Block—Copolymers via Controlled Radical Polymerization and CuAAC Conjugation

“Paintable” 3D printed structures via a post-ATRP process with antimicrobial function for biomedical applications

Bactericidal magnetic nanoparticles with iodine loaded on surface grafted poly(N-vinylpyrrolidone)

Preparation and characterization of block copolymers containing cinnamate groups with end-capped ZnO

Interaction between polyamines and bacterial outer membranes as investigated with ion-selective electrodes (2002)

Characterization of temperature-sensitive membranes prepared from poly(vinylidene fluoride)-graft-poly(N-isopropylacrylamide) copolymers obtained by atom transfer radical polymerization

Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli.

Controlled atom transfer radical polymerization of MMA onto the surface of high-density functionalized graphene oxide.

“Leaching or not leaching”: an alternative approach to antimicrobial materials via copolymers containing crown ethers as active groups

Similar Documents

ATRP of MMA in Aqueous Solution in the Presence of an Amphiphilic Polymeric Macroligand

Facile Synthesis of Well-Defined MDMO-PPV Containing (Tri)Block—Copolymers via Controlled Radical Polymerization and CuAAC Conjugation

“Paintable” 3D printed structures via a post-ATRP process with antimicrobial function for biomedical applications

Bactericidal magnetic nanoparticles with iodine loaded on surface grafted poly(N-vinylpyrrolidone)

Preparation and characterization of block copolymers containing cinnamate groups with end-capped ZnO

Interaction between polyamines and bacterial outer membranes as investigated with ion-selective electrodes (2002)

Characterization of temperature-sensitive membranes prepared from poly(vinylidene fluoride)-graft-poly(N-isopropylacrylamide) copolymers obtained by atom transfer radical polymerization

Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli.

Controlled atom transfer radical polymerization of MMA onto the surface of high-density functionalized graphene oxide.

“Leaching or not leaching”: an alternative approach to antimicrobial materials via copolymers containing crown ethers as active groups