NDLI: Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

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Tissue engineering with gellan gum

Recent progress in nanomaterials for gene delivery applications

Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery

Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification

Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold

Liquid crystalline nanoparticles encapsulating cisplatin and docetaxel combination for targeted therapy of breast cancer

The effects of poly(zwitterions)s versus poly(ethylene glycol) surface coatings on the biodistribution of protein nanoparticles

Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications

Heparin-based hydrogels with tunable sulfation & degradation for anti-inflammatory small molecule delivery

Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion

Nanofibrous polymeric beads from aramid fibers for efficient bilirubin removal

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Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

Content Provider	Royal Society of Chemistry (RSC)
Author	Mansfield, Edward D. H. Hole, Patrick Khutoryanskiy, Vitaliy V. Hoogenboom, Richard Kowalczyk, Radoslaw M. Sillence, Katy Rosa, Victor R. de la Grillo, Isabelle Williams, Adrian C.
Copyright Year	2016
Abstract	Functionalised nanomaterials are gaining popularity for use as drug delivery vehicles and, in particular, mucus penetrating nanoparticles may improve drug bioavailability via the oral route. To date, few polymers have been investigated for their muco-penetration, and the effects of systematic structural changes to polymer architectures on the penetration and diffusion of functionalised nanomaterials through mucosal tissue have not been reported. We investigated the influence of poly(2-oxazoline) alkyl side chain length on nanoparticle diffusion; poly(2-methyl-2-oxazoline), poly(2-ethyl-2-oxazoline), and poly(2-n-propyl-2-oxazoline) were grafted onto the surface of thiolated silica nanoparticles and characterised by FT-IR, Raman and NMR spectroscopy, thermogravimetric analysis, and small angle neutron scattering. Diffusion coefficients were determined in water and in a mucin dispersion (using Nanoparticle Tracking Analysis), and penetration through a mucosal barrier was assessed using an ex vivo fluorescence technique. The addition of a single methylene group in the side chain significantly altered the penetration and diffusion of the materials in both mucin dispersions and mucosal tissue. Nanoparticles functionalised with poly(2-methyl-2-oxazoline) were significantly more diffusive than particles with poly(2-ethyl-2-oxazoline) while particles with poly(2-n-propyl-2-oxazoline) showed no significant increase compared to the unfunctionalised particles. These data show that variations in the polymer structure can radically alter their diffusive properties with clear implications for the future design of mucus penetrating systems.
Starting Page	1318
Ending Page	1327
Page Count	10
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	4
Issue Number	9
Journal	Biomaterials Science
DOI	10.1039/c6bm00375c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Oxazoline Thermogravimetric analysis Nanoparticle Neutron diffraction Fluorescence Nanomaterials Polymer Nuclear magnetic resonance spectroscopy Drug delivery Mucus Bioavailability Fourier-transform infrared spectroscopy Methylene group Silicon dioxide Statistical dispersion Mucin Alkyl Nanoparticle tracking analysis Raman Propyl group Diffusion
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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Composite nanomaterials by self-assembly and controlled crystallization of poly(2-isopropyl-2-oxazoline)-grafted polysaccharides

Probing the Diffusion of Functionalised Nanoparticles in Gastric Mucin Using Nanoparticle Tracking Analysis

Unexpected thermal characteristics of aqueous solutions of poly(2-isopropyl-2-oxazoline)

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Phase behavior of poly(2-propyl-2-oxazoline)s

Intra-molecular interactions dominating the dehydration of a poly(2-isopropyl-2-oxazoline)-based densely grafted polymer comb in aqueous solution and hysteretic liquid–liquid phase separation

Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes.

Diverse expression patterns of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier.

Synthesis, characterisation, superoxide dismutase and catalase activities of functionalised silica nanoparticles

Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

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Composite nanomaterials by self-assembly and controlled crystallization of poly(2-isopropyl-2-oxazoline)-grafted polysaccharides

Probing the Diffusion of Functionalised Nanoparticles in Gastric Mucin Using Nanoparticle Tracking Analysis

Unexpected thermal characteristics of aqueous solutions of poly(2-isopropyl-2-oxazoline)

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Phase behavior of poly(2-propyl-2-oxazoline)s

Intra-molecular interactions dominating the dehydration of a poly(2-isopropyl-2-oxazoline)-based densely grafted polymer comb in aqueous solution and hysteretic liquid–liquid phase separation

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Diverse expression patterns of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier.

Synthesis, characterisation, superoxide dismutase and catalase activities of functionalised silica nanoparticles

Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier