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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Huang, Mingming Luo, Dan Li, Junjie Ge, Zhishen Zan, Minghui Luo, Shizhong Lin, Shanqing |
| Copyright Year | 2015 |
| Abstract | Near-infrared (NIR) light-triggered drug release systems are promising for drug delivery applications in view of the advantages of NIR light, which include high tissue penetration and low damage. In this report, we developed nanogels (NGs) by supramolecular self-assembly from adamantine (AD)-conjugated copolymer, poly[poly(ethylene glycol)monomethyl ether metharcylate]-co-poly(N-(2-hydroxypropyl)methacrylamide)-co-poly(N-adamantan-1-yl-2-methacrylamide) (PPEGMA-co-PHPMA-co-PADMA), and β-cyclodextrin (β-CD)-functionalized poly(amidoamine) (PAMAM) dendrimer based on the host–guest interaction of the AD and β-CD moieties, and they were used to encapsulate indocyanine green (ICG) and doxorubicin (DOX) for combined photothermal-chemotherapy. NGs simultaneously loading ICG and DOX (DINGs) showed significant photothermal effects and stimuli-triggered drug release under NIR laser irradiation by the photothermal-induced relaxation or dissociation of the NGs. In vitro cytotoxicity evaluation of DINGs under NIR irradiation demonstrated the synergistic effects of hyperthermia, photothermal-triggered drug release, and chemotherapy. In vivo investigation revealed their high accumulation in tumor tissue and significant tumor growth suppression under NIR irradiation. These NIR light-triggered drug release NGs represent efficient and promising anticancer drug vectors for the combined photothermal-chemotherapy of cancer to maximize therapeutic efficacy and minimize side effects. |
| Starting Page | 1147 |
| Ending Page | 1156 |
| Page Count | 10 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 3 |
| Issue Number | 7 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c5bm00048c |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Ethylene glycol Dendrimer Ether Cytotoxicity Drug delivery Indocyanine green Dissociative ICG Doxorubicin Self-assembly Chemotherapy NIR Laser Poly(amidoamine) Copolymer Hyperthermia Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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