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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Lee, Myung Kyu Kim, Jihoon Lee, Duhwan Lee, Yeong Mi Kim, Won Jong |
| Copyright Year | 2015 |
| Abstract | This work demonstrates successful delivery of a gene to EGFR-overexpressed cancer cells by using a rationally designed branched GE11 peptide as a targeting ligand. In addition, we exploited the effect of the divalent structure of the branched GE11 peptide on the gene delivery and tumor targeting efficiency, compared to the monovalent GE11 peptide. The GE11 or branched GE11-tethered polymers were successfully synthesized. They are composed of a targeting peptide, disulfide crosslinked low molecular weight polyethylenimine and polyethylene glycol. Here, we evaluated the physicochemical properties, cytotoxicity and in vitro transfection efficiency and in vivo biodistribution of the GE11 and branched GE11 tethered polyplexes. Our results demonstrated that GE11 and bGE11-tethered gene delivery carriers showed efficient gene condensing ability, an enhanced transfection efficiency and targeting ability with low cytotoxicity. Interestingly, the branched GE11-tethered polymer showed the greater targeting ability to EGFR-overexpressed cancer cells in vivo than the GE11-tethered polymer. Therefore, this branched structure of targeting ligand has the potential for providing a novel strategy to design an efficient targeted delivery system. |
| Starting Page | 1096 |
| Ending Page | 1104 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 3 |
| Issue Number | 7 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c5bm00004a |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Subscribed |
| Subject Keyword | Polyethylenimine Transfection Gene Ligand Polyethylene glycol Disulfide Signal peptide Cytotoxicity Polymer Peptide Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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